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Low-threshold (T-type) Ca(2+) channels encoded by the Ca(V)3 genes endow neurons with oscillatory properties that underlie slow waves characteristic of the non-rapid eye movement (NREM) sleep EEG. Three Ca(V)3 channel subtypes are expressed in the thalamocortical (TC) system, but their respective roles for the sleep EEG are unclear. Ca(V)3.3 protein is(More)
This paper presents the tool COMICS 1.0, which performs model checking and generates counterexamples for DTMCs. For an input DTMC, COMICS computes an abstract system that carries the model checking information and uses this result to compute a critical subsystem, which induces a counterexample. This abstract subsystem can be refined and concretized(More)
—Model checkers for concurrent probabilistic systems have become very popular within the last decade. The study of long-run average behavior has however received only scant attention in this area, at least from the implementation perspective. This paper studies the problem of how to efficiently realize an algorithm for computing optimal long-run average(More)
  • A Rebhan, P Van Nieuwenhuizen, R Wimmer
  • 2002
We show that the anomalous contribution to the central charge of the 1+1-dimensional N=1 supersymmetric kink that is required for BPS saturation at the quantum level can be linked to an analogous term in the extra momentum operator of a 2+1-dimensional kink domain wall with spontaneous parity violation and chiral domain wall fermions. In the quantization of(More)
  • A Rebhan, P Van Nieuwenhuizen, R Wimmer
  • 2002
We consider domain walls obtained by embedding the 1+1-dimensional φ 4-kink in higher dimensions. We show that a suitably adapted dimensional regularization method avoids the intricacies found in other regularization schemes in both supersymmetric and non-supersymmetric theories. This method allows us to calculate the one-loop quantum mass of kinks and(More)
Suboptimal developmental environments program offspring to lifelong health complications including affective and cognitive disorders. Little is known about the effects of suboptimal intra-uterine environments on associative learning and motivational behavior. We hypothesized that maternal isocaloric low protein diet during pregnancy and lactation would(More)
We present a uniform signature-based approach to compute the most popular bisimulations. Our approach is implemented symbolically using BDDs, which enables the handling of very large transition systems. Signatures for the bisimulations are built up from a few generic building blocks, which naturally correspond to efficient BDD operations. Thus, the(More)
Sleep spindles are synchronized 11-15 Hz electroencephalographic (EEG) oscillations predominant during nonrapid-eye-movement sleep (NREMS). Rhythmic bursting in the reticular thalamic nucleus (nRt), arising from interplay between Ca(v)3.3-type Ca(2+) channels and Ca(2+)-dependent small-conductance-type 2 (SK2) K(+) channels, underlies spindle generation.(More)
— This paper reports on our efforts to link an industrial state-of-the-art modelling tool to academic state-of-the-art analysis algorithms. In a nutshell, we enable timed reachability analysis of uniform continuous-time Markov decision processes, which are generated from STATEMATE models. We give a detailed explanation of several construction,(More)
This paper introduces a novel counterexample generation approach for the verification of discrete-time Markov chains (DTMCs) with two main advantages: (1) We generate abstract counterexamples which can be refined in a hierarchical manner. (2) We aim at minimizing the number of states involved in the counterexamples, and compute a critical subsystem of the(More)