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Low-threshold (T-type) Ca(2+) channels encoded by the Ca(V)3 genes endow neurons with oscillatory properties that underlie slow waves characteristic of the non-rapid eye movement (NREM) sleep EEG. Three Ca(V)3 channel subtypes are expressed in the thalamocortical (TC) system, but their respective roles for the sleep EEG are unclear. Ca(V)3.3 protein is(More)
We present a graphical toolset for verifying AADL models, which are gaining widespread acceptance in aerospace, automobile and avionics industries for comprehensively specifying safety-critical systems by capturing functional, probabilistic and hybrid aspects. Analyses are implemented on top of mature model checking tools and range from requirements(More)
This paper presents the tool COMICS 1.0, which performs model checking and generates counterexamples for DTMCs. For an input DTMC, COMICS computes an abstract system that carries the model checking information and uses this result to compute a critical subsystem, which induces a counterexample. This abstract subsystem can be refined and concretized(More)
—Model checkers for concurrent probabilistic systems have become very popular within the last decade. The study of long-run average behavior has however received only scant attention in this area, at least from the implementation perspective. This paper studies the problem of how to efficiently realize an algorithm for computing optimal long-run average(More)
Counterexamples for property violations have a number of important applications like supporting the debugging of erroneous systems and verifying large systems via counterexample-guided abstraction refinement. In this paper, we propose the usage of minimal critical subsystems of discrete-time Markov chains and Markov decision processes as counterexamples for(More)
Suboptimal developmental environments program offspring to lifelong health complications including affective and cognitive disorders. Little is known about the effects of suboptimal intra-uterine environments on associative learning and motivational behavior. We hypothesized that maternal isocaloric low protein diet during pregnancy and lactation would(More)
State explosion problem: Systems often consist of hundreds of millions of states. Bisimulations provide: Minimization of state spaces Equivalence checking of systems w. r. t. some observable behaviour. State explosion problem: Systems often consist of hundreds of millions of states. Bisimulations provide: Minimization of state spaces Equivalence checking of(More)
Sleep spindles are distinctive electroencephalographic (EEG) oscillations emerging during non-rapid-eye-movement sleep (NREMS) that have been implicated in multiple brain functions, including sleep quality, sensory gating, learning, and memory. Despite considerable knowledge about the mechanisms underlying these neuronal rhythms, their function remains(More)
Behavioral state is known to influence interactions between thalamus and cortex, which are important for sensation, action, and cognition. The thalamic reticular nucleus (TRN) is hypothesized to regulate thalamo-cortical interactions, but the underlying functional architecture of this process and its state dependence are unknown. By combining the first TRN(More)
Since its introduction in 1999, bounded model checking has gained industrial relevance for detecting errors in digital and hybrid systems. One of the main reasons for this is that it always provides a counterexample when an erroneous execution trace is found. Such a counterexample can guide the designer while debugging the system. In this paper we are(More)