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Indium-111 labelledDTPA-d-Phe1-octreotide (DTPA-OC, OctreoScan) has been introduced into clinical routine for the detection of somatostatin receptor (SSTR)-positive tumours, which are predominantly of neuroendocrine origin. Potential further applications in other SSTR-positive cancers (e.g. small cell lung cancer, breast cancer, melanoma) have been limited(More)
We report on a patient with a follicular Hurthle cell carcinoma in whom distant metastases were initially radioiodine negative or only weakly positive. Redifferentiation therapy with 13-cis retinoic acid induced a significant radioiodine uptake in metastatic tissue. Thyroglobulin (Tg) immunostaining and autoradiography of a bone metastasis in the right(More)
UNLABELLED Due to a dedifferentiation of tumor cells, some thyroid carcinomas lose their capability for radioiodine (RI) concentration. This phenomenon is associated with a worse prognosis and prevents effective treatment. Retinoic acid (RA) is known to induce redifferentiation in various kinds of tumors and has been used recently in thyroid cancer. (More)
PURPOSE Pectus carinatum is a thoracic deformity, which causes severe psychological problems for affected patients but almost no physical limitations. Invasive procedures are difficult to justify for this reason. We present a conservative therapy which leads to complete resolution in most cases when performed properly. METHODS Between January 2008 and(More)
AIM It is well known that radioiodine therapy (RITh) leads to a significant thyroid volume reduction (TVR). But until now only little data has been presented due to the course of time and the extent of TVR. METHOD Therefore the data of 33 patients with Graves' disease (GD), 36 patients with multifocal (MAG) and 31 with solitary (SAG) autonomous goitre(More)
We have found, in 7-day pokeweed mitogen stimulated cultures of peripheral blood mononuclear cells, a marked deficiency in aged men (over 75 years) in maturation of B cells to antibody-producing cells. This finding was equally true whether maturation was measured by B cells with the specific function of producing anti-sheep erythrocyte plaques or by the(More)
By use of monoclonal antibodies and flow cytometry techniques, peripheral blood mononuclear cells from young (20-30 years) and elderly (70+ years) subjects were analyzed before and after culture with pokeweed mitogen to gain insight into the cellular interactions responsible for the decreased B cell response observed in culture samples from the elderly.(More)