Ralf Kretschmer

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The pharmacokinetics of the immunosuppressive agent cyclosporin-A (CsA) were studied in rats submitted to spinal cord (SC) injury. A single CsA 10 mg/kg dose was given either intraperitoneally (i.p.) or orally to rats submitted to experimental SC injury at the T8 level. Twenty four hours after lesion (acute stage of SC injury) i.p. CsA bioavailability was(More)
The aim of this investigation was to determine whether an actual acceleration in dental development has taken place over the last 30 years in a European population group, as is so readily observable in relation to body height. In this study, radiographs of 1038 healthy European children, 516 boys and 522 girls, were evaluated. The methodology and norms(More)
Screening of 8918 pregnant women revealed that 107 (1.2%) were HBsAg-positive. 92 of them (50 of German and 42 of predominantly Asian origin) have already delivered and were followed up for 12 months together with their infants. 14 infants of HBeAg-positive (or anti-HBe-negative) carrier mothers received a single dose of hepatitis B immunoglobulin (HBIG)(More)
Pharmacokinetics (PK) of drugs such as gentamicin and theophylline is altered in humans with spinal cord (SC) injury (Segal, 1985). These observations led us to suspect that the PK of cyclosporine-A (CsA) might be altered in experimental SC injury. Our goal was to establish the best immunosuppressive strategy with CsA for our rat model of traumatic SC(More)
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