Ralf Kirsch

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The QuikChangeTM protocol is one of the simplest and fastest methods for site-directed mutagenesis, but introduces mutations at only one site at a time, and requires two HPLC-purified complementary oligonucleotides. Here, we describe that this method can be used with non-overlapping oligonucleotides. By doing this, two separate sites can be mutagenised(More)
We present new estimates of the Boltzmann collision operator in weighted Lebesgue and Bessel potential spaces. The main focus is put on hard potentials under the assumption that the angular part of the collision kernel fulfills some weighted integrability condition. In addition, the proofs for some previously known L p-estimates have been considerably(More)
DNA microarray analysis provides a powerful tool for determining changes in gene expression on a genome wide scale. The chromatin modifying agents 5-Aza-2'-deoxycytidine (AzaC) and Trichostatin A (TSA) alter the developmental potential of neurosphere cells and make them acquire hematopoietic activity[1]. TSA and AzaC alter chromatin status and thus alter(More)
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