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A sample of 492 full heritage, unrelated residents of the Gila River Indian Community (GRIC) of Arizona were characterized for their high-resolution DNA alleles at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci. Only five allelic categories are found at HLA-A, 10 at HLA-B, 8 at HLA-C and HLA-DR, and 4 at DQA1 and DQB1. There is little evidence for population(More)
A total of 42,160 individuals were typed for HLA-A and HLA-B by both serology and PCR-based typing. The HLA assignments included all of the known serological equivalents. The majority of the individuals (99.9%) were from U.S. minority population groups. The serologic typing was performed between 1993 and 1997 at the time of recruitment for the National Bone(More)
DNA-based typing of HLA class I alleles of the HLA-A and HLA-B loci using sequence-specific oligonucleotide primers and/or probes has been used for the large-scale typing of individuals for the National Marrow Donor Program unrelated donor registry. Typing was performed by 16 laboratories at a low level of resolution (e.g. A*01, B*07). The results of(More)
A series of novel benzoxazole derivatives has been designed and shown to exhibit attractive JAK2 inhibitory profiles in biochemical and cellular assays, capable of delivering compounds with favorable PK properties in rats. Synthesis and structure-activity relationship data are also provided.
Oxysterols have recently been identified as natural ligands for a G protein-coupled receptor called EBI2 (aka GPR183) ( Nature 2011 , 475 , 524 ; 519 ). EBI2 is highly expressed in immune cells ( J. Biol. Chem. 2006 , 281 , 13199 ), and its activation has been shown to be critical for the adaptive immune response and has been genetically linked to(More)
O. Gayou,1,7 K. A. Aniol,9 T. Averett,1 F. Benmokhtar,2 W. Bertozzi,24 L. Bimbot,26 E. J. Brash,4 J. R. Calarco,25 C. Cavata,27 Z. Chai,24 C.-C. Chang,23 T. Chang,15 J.-P. Chen,5 E. Chudakov,5 R. De Leo,16 S. Dieterich,2 R. Endres,2 M. B. Epstein,9 S. Escoffier,27 K. G. Fissum,22 H. Fonvieille,7 S. Frullani,18 J. Gao,8 F. Garibaldi,18 S. Gilad,24 R.(More)
The ratio of the electric and magnetic form factors of the proton G(E(p))/G(M(p)), which is an image of its charge and magnetization distributions, was measured at the Thomas Jefferson National Accelerator Facility (JLab) using the recoil polarization technique. The ratio of the form factors is directly proportional to the ratio of the transverse to(More)
In this work, we report on the fabrication and characterization of voltage-programmable (VP) nanowire (NW) field-effect-transistor (FET) devices suitable to extend the flexibility in circuit design, i.e. of reconfigurable logic. Ultra-thin silicon NW-structures with mid-gap Schottky S/D junctions on silicon-on-insulator (SOI) substrate have been fabricated(More)