Ralf Dieter Hilgers

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Ten of 11 patients with ovarian cancer receiving cisplatin developed a distal sensory neuropathy, manifested early by decreased vibratory sensibility in toes and depressed ankle jerks and later by uncomfortable paresthesias. Eleven patients receiving cisplatin, 50 mg/m2 monthly (mean total, 580 mg/m2) were studied prospectively with monthly neurologic(More)
PURPOSE To report the use of perfluorohexyloctane, a liquid semifluorinated alkane that is heavier than water, as an internal tamponade agent in surgery for complicated retinal detachments. DESIGN A consecutive interventional case series from three study centers. METHODS In 23 consecutive eyes (23 patients, 19 men and four women, mean +/- standard(More)
The study describes the application of the Arsenazo III method for detection of minimal amounts of calcium 12.4-49.4 micromol/l in different acidic solutions (hydrochloric acid, oxalic acid, maleic acid, phosphoric acid, tartaric acid, citric acid, lactic acid and acetic acid) adjusted to pH 2.0, 2.3 and 3.0. A mixture of the respective calcium(More)
OBJECTIVES Sleep apnoea is common in active acromegaly. It is associated with increased morbidity and mortality but can be treated effectively. The objective of this study was to determine the largely unknown relative frequency of, and the predictive factors for, sleep apnoea in treated acromegalic patients. DESIGN Retrospective cohort study. SETTING(More)
Unilateral transection and suture of the facial nerve was performed in 60 old rats (20 months of age). The time course of mimetic reinnervation was studied by counting all retrogradely labeled motoneurons in the facial nucleus after injection of HRP into the whiskerpad muscles for 14-112 days post operation. The comparison between these neuron counts and(More)
AIM The etiology of hypercirculatory instability following cardiac surgery with cardiopulmonary bypass has not yet been completely investigated and its clinical impact remains unclear. This prospective study was undertaken in order to investigate the impact of the systemic infusion of high volume crystalloid cardioplegia on the incidence of hypercirculatory(More)
PURPOSE To assess the efficacy and safety of adjunctive daunorubicin during vitrectomy surgery in eyes with idiopathic proliferative vitreoretinopathy (PVR). METHODS Two hundred eighty-six eyes (286 patients) with stage C2 (Retina Society Classification, 1983) or more advanced preoperative PVR in which surgery with silicone oil was planned were enrolled(More)
OBJECTIVE To assess long-term functional and morphological changes after macular translocation in patients with exudative age-related macular degeneration. METHODS Evaluation of a noncomparative cohort study of 90 patients with a follow-up of 14 to 79 months (mean, 38.2 months). RESULTS Visual acuity increased by 3 or more lines in 15 patients, remained(More)
RATIONALE AND OBJECTIVES To optimize the intraluminal signal intensity of a nitinol stent by performing contrast-enhanced three-dimensional magnetic resonance angiography (CE-MRA) with varying flip angles (FAs). METHODS Contrast-enhanced magnetic resonance angiography at 1.5 T and FAs of 30 degrees, 100 degrees, and 150 degrees was performed on five sheep(More)
Standardized class 4 cavities were prepared in bovine incisors and restored with a microfilled composite resin. The composite restorations were retained either by acid etching technique (AET) alone or by acid etching technique in combination with a self-threading retentive pin. Pins covered with a bonding/opaquer coating (PCR pin) and uncovered pins (FO(More)