Rakshita A. Charan

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Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is an important cause of dementia in individuals under age 65. Common variants in the TMEM106B gene were previously discovered by genome-wide association to confer genetic risk for FTLD-TDP (p = 1 × 10-11, OR = 1.6). Furthermore, TMEM106B may act as a genetic modifier affecting age at onset(More)
Mutations in the E3 ligase parkin are the most common cause of autosomal recessive Parkinson's disease (PD), but it is believed that parkin dysfunction may also contribute to idiopathic PD. Since its discovery, parkin has been implicated in supporting multiple neuroprotective pathways, many revolving around the maintenance of mitochondrial health quality(More)
Parkinson disease (PD) is a common neu-rodegenerative disorder affecting about 1–2% of the population over the age of 65. 1 While most PD cases are sporadic, the rare, familial forms can provide unique insight into disease processes. Mutations within the PARK2 locus, which encodes the ubiquitin E3 ligase parkin, 2 are the most common cause of autosomal(More)
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