Rakshita A. Charan

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Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, affecting 1-3% of the population over 65. Mutations in the ubiquitin E3 ligase parkin are the most common cause of autosomal recessive PD. The parkin protein possesses potent cell-protective properties and has been mechanistically linked to both the regulation of apoptosis and(More)
Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) are involved in acetylcholine synthesis and degradation at pre- and postsynaptic compartments, respectively. Here we show that their anterograde transport in Drosophila larval ganglion is microtubule-dependent and occurs in two different time profiles. AChE transport is constitutive while that(More)
Parkinson disease (PD) is a common neu-rodegenerative disorder affecting about 1–2% of the population over the age of 65. 1 While most PD cases are sporadic, the rare, familial forms can provide unique insight into disease processes. Mutations within the PARK2 locus, which encodes the ubiquitin E3 ligase parkin, 2 are the most common cause of autosomal(More)
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