Rakshita A. Charan

Learn More
Mutations in the E3 ligase parkin are the most common cause of autosomal recessive Parkinson's disease (PD), but it is believed that parkin dysfunction may also contribute to idiopathic PD. Since its discovery, parkin has been implicated in supporting multiple neuroprotective pathways, many revolving around the maintenance of mitochondrial health quality(More)
Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) are involved in acetylcholine synthesis and degradation at pre- and postsynaptic compartments, respectively. Here we show that their anterograde transport in Drosophila larval ganglion is microtubule-dependent and occurs in two different time profiles. AChE transport is constitutive while that(More)
Parkinson disease (PD) is a common neu-rodegenerative disorder affecting about 1–2% of the population over the age of 65. 1 While most PD cases are sporadic, the rare, familial forms can provide unique insight into disease processes. Mutations within the PARK2 locus, which encodes the ubiquitin E3 ligase parkin, 2 are the most common cause of autosomal(More)
  • 1