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Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer
TLDR
It is suggested that intracellularly generated salicylic acid metabolites through CYP450 enzymes within the colonic epithelial cells, or the salicyolic acid metabolites generated by gut microflora may significantly contribute to the preferential chemopreventive effect of aspirin against CRC through inhibition of CDKs. Expand
In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes
TLDR
The in vivo results with C57BL/6 mice implanted subcutaneously with B16-F10 cells showed that GSSG liposomes retarded tumor proliferation more effectively than that of dacarbazine, a chemotherapeutic drug for the treatment of melanoma. Expand
Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention
TLDR
It is demonstrated that aspirin and salicylic acid downregulate cyclin A2/CDK2 proteins in multiple cancer cell lines, suggesting a novel target and mechanism of action in chemoprevention. Expand
Aspirin and salicylic acid decrease c-Myc expression in cancer cells: a potential role in chemoprevention
TLDR
It is demonstrated that aspirin and its primary metabolite, salicylic acid, decrease the c-Myc protein levels in human HCT-116 colon and in few other cancer cell lines, and suggests that salicyric acid regulates c- myc level at both transcriptional and post-transcription levels. Expand
Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53
TLDR
It is demonstrated that aspirin induced acetylation of p53 in both cell lines in a concentration-dependent manner and the results suggest that aspirin’s anti-cancer effect may involve acetylated and activation of wild type and mutant p53 and induction of target gene expression. Expand
Site‐directed non‐covalent polymer‐drug complexes for inflammatory bowel disease (IBD): Formulation development, characterization and pharmacological evaluation
TLDR
Ora‐Curcumin‐S significantly prevented colitis and associated injury in a mouse model of ulcerative colitis estimated using multiple preclinical parameters: colonoscopy pictures, body weight, colon length, colon edema, spleen weight, pro‐inflammatory signaling and independent pathological scoring. Expand
Aspirin inhibits glucose-6-phosphate dehydrogenase activity in HCT 116 cells through acetylation: Identification of aspirin-acetylated sites
TLDR
The results demonstrated that the extent of G6PD acetylation was significantly higher in HCT 116 cells compared with in HT-29 cells, which may contribute to the ability of aspirin to exert anticancer effects through decreased synthesis of ribose sugars and NADPH. Expand
In Vitro and In Vivo Antimetastatic Effect of Glutathione Disulfide Liposomes
TLDR
The data demonstrate that GSSG liposomes at 1 mg/mL completely blocked cell detachment and migration, and significantly inhibited cancer cell invasion, and the unique antimetastatic mechanism through the effects on detachment and migrating, warrants further investigation of the G SSGliposomes as a potential treatment for cancer metastasis. Expand
Hydrophobically modified inulin-based micelles: Transport mechanisms and drug delivery applications for breast cancer
Abstract Carbohydrate-based polymers are gaining interest as drug delivery materials with improved safety profile and cost effectiveness. Understanding the cellular uptake mechanisms of nanoparticleExpand
Aspirin metabolites 2,3-DHBA and 2,5-DHBA inhibit cancer cell growth: Implications in colorectal cancer prevention
TLDR
It is suggested that 2,3- DHBA and 2,5-DHBA may contribute to the chemopreventive properties of aspirin, possibly through the inhibition of CDKs. Expand
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