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Studies on the utilization of citrus peel for pectinase production using fungus Aspergillus niger
The fruit processing industries produce a large amount of waste material, which poses considerable disposal problems and ultimately leads to pollution. In the processing of citrus fruits, a largeExpand
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Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel.
INTRODUCTION The hERG (human ether-a-go-go related gene) potassium channel is required for normal cardiac repolarization, is susceptible to inhibition by a wide variety of compounds, and its blockageExpand
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Development and validation of HTS flux assay for endogenously expressed chloride channels in a CHO-K1 cell line.
An atomic absorption spectroscopy-based detection system was employed to develop a new non-radioactive flux assay for chloride (Cl-) channels in a high throughput format. Cl- flux is assayed byExpand
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A High-Throughput Screening Assay for NKCC1 Cotransporter Using Nonradioactive Rubidium Flux Technology.
A high-throughput screening (HTS) assay was developed for cotransporter, NKCC1, which is a potential target for the treatment of diverse disorders. This nonradioactive rubidium flux assay coupledExpand
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Development of an HTS assay for Na+, K+-ATPase using nonradioactive rubidium ion uptake.
A high-throughput screening (HTS) assay was developed for the Na(+),K(+)-ATPase channel in order to study rubidium uptake as a measure of the functional activity and modulation of this exchanger. TheExpand
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A cell-based Rb(+)-flux assay of the Kv1.3 potassium channel.
The Kv1.3 channels expressed by human T lymphocytes are emerging as important therapeutic targets. Peptides like agitoxin and margatoxin in scorpion venom and some non-peptide small molecules areExpand
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Abstracts of Papers Presented at the 2008 Pittsburgh Conference
tl;dr
A model for projecting productivity improvements resulting from the introduction of laboratory informatics solutions . Expand
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A High Throughput Screening Technology-Overcoming Bottlenecks in Ion Channel Drug Targets
Ion Channels as therapeutic targets: Ion channels are transmembrane proteins that allow the formation of a concentration gradient between the extracellular and intracellular contents. Three majorExpand
Validation of a Rb+ uptake assay for the mouse embryonic stem cell-derived cardiomyocytes Na+, K+ ATPase.
Human Na+, K+ ATPase, an ATP-driven ion transporter, is an emerging drug target for heart-related conditions. Three types of assays including purified enzyme, radiotracer flux, and cold Rb+ flux haveExpand
Skeletal muscle phosphatidylcholine fatty acids and insulin sensitivity in normal humans.
The fatty acid composition of skeletal muscle membrane phospholipids (PL) is known to influence insulin responsiveness in humans. However, the contribution of the major PL of the outerExpand