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Teriflunomide is an oral disease-modifying therapy recently approved in several locations for relapsing-remitting multiple sclerosis. To gain insight into the effects of teriflunomide, immunocyte population changes were measured during progression of experimental autoimmune encephalomyelitis in Dark Agouti rats. Treatment with teriflunomide attenuated(More)
UNLABELLED Hepatocellular carcinoma (HCC) remains a significant clinical challenge with few therapeutic options available to cancer patients. MicroRNA 21-5p (miR-21) has been shown to be upregulated in HCC, but the contribution of this oncomiR to the maintenance of tumorigenic phenotype in liver cancer remains poorly understood. We have developed potent and(More)
Following in vitro demonstration of dependence of synaptosoma'l preparation on divalent cations for neurotransmitter precursor uptake particularly of tyrosine and tryptophan and evolution of biogenic theory of causation and therapeutic response to monoamine oxidase (MAO) inhibitors in affective disorders, blood electrolytes have gained considerable(More)
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