Rajneesh Tripathi

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The implications of the methylene tetrahydrofolate reductase (MTHFR) gene and the level of homocysteine in the pathogenesis of coronary artery disease (CAD) have been extensively studied in various ethnic groups. Our aim was to discover the association of MTHFR (C677T) polymorphism and homocysteine level with CAD in north Indian subjects. The study group(More)
BACKGROUND & OBJECTIVES A surface glycoprotein molecule, E-selectin is involved in adhesion of circulating leukocyte to the activated endothelium and plays a fundamental role in pathogenesis of atherosclerosis. The present study was undertaken to document the status of S128R polymorphism of E-selectin gene in angiographically proven coronary artery disease(More)
BACKGROUND Control of the global burden of tuberculosis is obstructed due to lack of simple, rapid and cost effective diagnostic techniques that can be used in resource poor-settings. To facilitate the early diagnosis of TB directly from clinical specimens, we have standardized and validated the use of nested multiplex PCR, targeting gene fragments IS6110,(More)
Detection of drug resistance in Mycobacterium tuberculosis by conventional phenotypic drug susceptibility testing methods requires several weeks. Therefore, molecular diagnostic tests for rapid detection of multidrug resistance tuberculosis (MDR-TB) are urgently needed. Early diagnosis helps in initiating optimal treatment which would not only enable cure(More)
The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is expressed on the endothelial cells, macrophages, and vascular smooth muscle cells. It internalizes Ox-LDL leading to multiple effects on endothelial dysfunctions and atherosclerosis (Knowles et al., 2008). The expression of OLR1 gene has been observed in vivo (placenta, lungs,(More)
BACKGROUND Drug resistance in tuberculosis is a major public health challenge in developing countries. The limited data available on drug resistance in extra pulmonary tuberculosis stimulated us to design our study on anti-tuberculosis drug resistance pattern in cases of extra pulmonary tuberculosis in a tertiary referral hospital of North India. We(More)
Lipoprotein lipase (LPL) is a key enzyme for the hydrolysis of triglycerides in the core of chylomicrons and very low-density lipoprotein (Goldberg and Merkel 2001). The various substitutions in the LPL gene have been reported to play roles in the development of dyslipidemia in the general population (Razzaghi et al. 2000; Jap et al. 2003; Yang et al.(More)
Hereditary hemochromatosis is an autosomal recessive and most commonly inherited single gene disorder among Caucasians, with a prevalence of 5 per 1,000 and a carrier frequency of 1 in 10. Two point mutations were described and are referred as C282Y and H63D. In the present study, we have analyzed 729 north Indian samples for C282Y and H63D mutations. Of(More)
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