Despite the dramatic increase in speed of synthesis and biological evaluation of new chemical entities, the number of compounds that survive the rigorous processes associated with drug development is low. Thus, an increased emphasis on thorough ADMET (absorption, distribution, metabolism, excretion and toxicity) studies based on in vitro and in silico… (More)
Two ultracompact H ii regions (IRAS 19181+1349 and 20178+4046) and one compact molecular clump (20286+4105) have been observed at far infrared wavelengths using the TIFR 1 m balloon-borne telescope and at mid infrared wavelengths using ISO. Far infrared observations have been made simultaneously in two bands with effective wavelengths of ∼ 150 and ∼210 µm,… (More)
Psychosis with phenytoin use has earlier been reported only in the context of Vitamin B12 or folic acid deficiency. We report a rare case of phenytoin toxicity manifesting as psychosis in the absence of Vitamin deficiency. The importance of recognition of psychosis as a harbinger of phenytoin toxicity and implications for management are discussed.
High resolution far-infrared observations of a large area of the star forming complex RCW 106 obtained using the TIFR 1m balloon-borne telescope are presented. Intensity maps have been obtained simultaneously in two bands centred around 150 and 210 µm. Intensity maps have also been obtained at the four IRAS bands using HIRES processed IRAS data. From the… (More)
A new scheme of radiation transfer for understanding infrared spectra of H II regions, has been developed. This scheme considers non-equilibrium processes (e.g. transient heating of the very small grains, VSG; and the polycyclic aromatic hydrocarbon, PAH) also, in addition to the equilibrium thermal emission from normal dust grains (BG). The spherically… (More)