Rajesh Tota-Maharaj

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AIMS To determine if coronary artery calcium (CAC) scoring is independently predictive of mortality in young adults and in the elderly population and if a young person with high CAC has a higher mortality risk than an older person with less CAC. METHODS AND RESULTS We studied a cohort of 44 052 asymptomatic patients referred for CAC scans for(More)
OBJECTIVE To describe ethnic and sex differences in the prevalence and determinants of fatty liver in a multiethnic cohort. PATIENTS AND METHODS We studied participants of the Multi-Ethnic Study of Atherosclerosis who underwent baseline noncontrast cardiac computed tomography between July 17, 2000, and August 29, 2002, and had adequate hepatic and splenic(More)
OBJECTIVE To evaluate the association of coronary artery calcium (CAC) and coronary heart disease (CHD) events among young and elderly individuals. PARTICIPANTS AND METHODS This is a secondary analysis of data from a prospective, multiethnic, population-based cohort study designed to study subclinical atherosclerosis. A total of 6809 persons 45 through 84(More)
PURPOSE OF REVIEW Novel research over the past 2 years has necessitated an update of our 'ABCDE' approach to the metabolic syndrome. RECENT FINDINGS Clinical trials investigating the role of aspirin in primary prevention have led to an adjustment in the indication for aspirin in metabolic syndrome patients at intermediate risk of a cardiovascular event.(More)
Increased uric acid (UA) is strongly linked to cardiovascular disease. However, the independent role of UA is still debated because it is associated with several cardiovascular risk factors including obesity and metabolic syndrome. This study assessed the association of UA with increased high-sensitivity C-reactive protein (hs-CRP), increased ratio of(More)
OBJECTIVES The aim of this study was to investigate whether inclusion of simple measures of calcified plaque distribution might improve the ability of the traditional Agatston coronary artery calcium (CAC) score to predict cardiovascular events. BACKGROUND Agatston CAC scoring does not include information on the location and distributional pattern of(More)
BACKGROUND The Agatston coronary artery calcium (CAC) score predicts cardiovascular events through its association with overall burden of coronary atherosclerosis. It is unclear whether adding regional measures of CAC distribution to the Agatston score improves this association. METHODS We studied 920 consecutive patients (mean age 57 ± 12, 53% female),(More)
Although the traditional Agatston coronary artery calcium (CAC) score is a powerful predictor of mortality, it is unknown if the regional distribution of CAC further improves cardiovascular risk prediction. We retrospectively studied 23,058 patients referred for Agatston CAC scoring, of whom 61% had CAC (n=14,084). CAC distribution was defined as the number(More)
BACKGROUND Little is known about the independent impact of aging on coronary plaque morphology and composition in the era of cardiac computed tomography angiography (CCTA). METHODS We studied 1015 consecutive asymptomatic South Korean subjects (49 ± 10 years, 64% men) who underwent 64-slice CCTA during routine health evaluation. Coronary plaque(More)
BACKGROUND Risk assessment in the extensive calcified plaque phenotype has been limited by small sample size. OBJECTIVE We studied all-cause mortality rates among asymptomatic patients with markedly elevated Agatston scores > 1000. METHODS We studied a clinical cohort of 44,052 asymptomatic patients referred for coronary calcium scans. Mean follow-up(More)