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Systematic Analysis of Small RNAs Associated with Human Mitochondria by Deep Sequencing: Detailed Analysis of Mitochondrial Associated miRNA
TLDR
This is the first systematic study demonstrating the associations of sRNA including miRNA with mitochondria that may regulate site-specific turnover of target mRNA important for mitochondrial related functions.
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Morphological characterization of very small embryonic-like stem cells (VSELs) by ImageStream system analysis
TLDR
It is demonstrated by all of the sensitive and precise methods employed, that VSELs are a population of very small cells, which are significantly smaller than haematopoetic stem cells (HSC) (3.63 ± 0.09 versus 6.54 ±0.17 μm in diameter).
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CXCR3 axis: role in inflammatory bowel disease and its therapeutic implication.
TLDR
While it is demonstrated that antibodies directed against CXCL10 could both prevent the onset and cure of pre-existing colitis in IL-10(-/-) mice, studies by other investigators have shown the efficacy of CXCR3 blockade to mitigate colitis and other inflammatory diseases.
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TNF-α regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells.
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CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells
TLDR
It is demonstrated that CCR5 and CCL5 are potential markers for metastatic PC cancer, and their interaction leads to the increased PC cell invasion, and blocking C CR5/CCL5 axis might prove beneficial to prevent metastasis and provide a more therapeutic strategy to control PC progression.
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Severe hyperthyroidism induces mitochondria‐mediated apoptosis in rat liver
TLDR
Evidence is provided that excess T3 causes liver dysfunction by inducing apoptosis, as a result of activation of a mitochondria‐dependent pathway, which provides an explanation for liver dysfunction associated with hyperthyroidism.
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Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion.
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Challenges in liver cancer and possible treatment approaches.
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Mitochondria: one of the destinations of miRNAs.
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Correction for Gururaj et al., MTA1, a transcriptional activator of breast cancer amplified sequence 3
TLDR
It is discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase II complex to the BCAS3 enhancer sequence.
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