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Systematic Analysis of Small RNAs Associated with Human Mitochondria by Deep Sequencing: Detailed Analysis of Mitochondrial Associated miRNA
- Lakshmi Sripada, D. Tomar, P. Prajapati, Rochika Singh, A. Singh, Rajesh Singh
- BiologyPloS one
- 11 September 2012
This is the first systematic study demonstrating the associations of sRNA including miRNA with mitochondria that may regulate site-specific turnover of target mRNA important for mitochondrial related functions.
Morphological characterization of very small embryonic-like stem cells (VSELs) by ImageStream system analysis
- E. Zuba-Surma, M. Kucia, M. Ratajczak
- BiologyJournal of cellular and molecular medicine
- 20 November 2007
It is demonstrated by all of the sensitive and precise methods employed, that VSELs are a population of very small cells, which are significantly smaller than haematopoetic stem cells (HSC) (3.63 ± 0.09 versus 6.54 ±0.17 μm in diameter).
CXCR3 axis: role in inflammatory bowel disease and its therapeutic implication.
- U. Singh, C. Venkataraman, Rajesh Singh, J. Lillard
- Biology, MedicineEndocrine, metabolic & immune disorders drug…
- 31 May 2007
While it is demonstrated that antibodies directed against CXCL10 could both prevent the onset and cure of pre-existing colitis in IL-10(-/-) mice, studies by other investigators have shown the efficacy of CXCR3 blockade to mitigate colitis and other inflammatory diseases.
TNF-α regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells.
CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells
- S. Singh, M. Mishra, I. Eltoum, S. Bae, J. Lillard, Rajesh Singh
- Biology, MedicineScientific Reports
- 22 January 2018
It is demonstrated that CCR5 and CCL5 are potential markers for metastatic PC cancer, and their interaction leads to the increased PC cell invasion, and blocking C CR5/CCL5 axis might prove beneficial to prevent metastasis and provide a more therapeutic strategy to control PC progression.
Severe hyperthyroidism induces mitochondria‐mediated apoptosis in rat liver
- G. Upadhyay, Rajesh Singh, Ashok Kumar, Sanjeev Kumar, A. Kapoor, M. Godbole
- Biology, MedicineHepatology
- 1 April 2004
Evidence is provided that excess T3 causes liver dysfunction by inducing apoptosis, as a result of activation of a mitochondria‐dependent pathway, which provides an explanation for liver dysfunction associated with hyperthyroidism.
Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion.
Challenges in liver cancer and possible treatment approaches.
Mitochondria: one of the destinations of miRNAs.
Correction for Gururaj et al., MTA1, a transcriptional activator of breast cancer amplified sequence 3
- Anupama E. Gururaj, Rajesh Singh, Rakesh Kumar
- Biology, MedicineProceedings of the National Academy of Sciences
- 25 April 2006
It is discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase II complex to the BCAS3 enhancer sequence.