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Aurora kinases play a critical role in regulating mitosis and cell division, and their overexpression has been implicated in the survival and proliferation of human cancer. In this study, we report the in vitro and in vivo activities of AZD1152, a compound that has selectivity for aurora B kinase, in acute myeloid leukemia (AML) cell lines, primary AML(More)
CHR-2797 is a novel metalloenzyme inhibitor that is converted into a pharmacologically active acid product (CHR-79888) inside cells. CHR-79888 is a potent inhibitor of a number of intracellular aminopeptidases, including leucine aminopeptidase. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows(More)
BACKGROUND The Ras/RAF/MEK/ERK pathway is frequently deregulated in cancer and a number of inhibitors that target this pathway are currently in clinical development. It is likely that clinical testing of these agents will be in combination with standard therapies to harness the apoptotic potential of both the agents. To support this strategy, it has been(More)
The synthesis of dimethylzinc (Me 2 Zn) and diethylzinc (Et 2 Zn) by Frankland in the mid-nineteenth century marks a cornerstone in the history of chemistry. [1] Not only were they among the first organometallic compounds, but studies on their chemical reactions and vapor densities led to the first clear exposition of valency theory. [2] Since then both(More)
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