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The contrast-to-noise ratio (CNR) is often very low in fMRI data, and standard univariate methods suffer from a loss of sensitivity in the context of noise. The increased power of a multivariate statistical analysis method known as canonical correlation analysis (CCA) in fMRI studies with low CNR was established previously. However, CCA in its conventional(More)
Functional magnetic resonance imaging (fMRI) is an important imaging modality to understand the neurodegenerative course of mild cognitive impairment (MCI) and early Alzheimer's disease (AD), because the memory dysfunction may occur before structural degeneration is obvious. In this research, we investigated the functional abnormalities of subjects with(More)
BACKGROUND Mobile technology provides new opportunities for health promotion communication. The purpose of this study was to conduct a current and extensive meta-analytic review of SMS (short message service) text message-based interventions for individual smoking cessation. METHODS Academic Search Complete, PsycINFO, PubMed, and Scopus were reviewed for(More)
The current fMRI study investigated correlations of low-frequency signal changes in the left inferior frontal gyrus, right inferior frontal gyrus and cerebellum in 13 adult dyslexic and 10 normal readers to examine functional networks associated with these regions. The extent of these networks to regions associated with phonological processing (frontal(More)
The major disadvantage of hierarchical clustering in fMRI data analysis is that an appropriate clustering threshold needs to be specified. Upon grouping data into a hierarchical tree, clusters are identified either by specifying their number or by choosing an appropriate inconsistency coefficient. Since the number of clusters present in the data is not(More)
Detection of activation in functional MRI (fMRI) is often complicated by the low contrast-to-noise ratio (CNR) in the data. The primary source of the difficulty is the fact that for activities that are subtle the signal can be hidden inside the inherent noise in the data. Classical univariate methods based on t-test or F-test are susceptible to noise, as(More)
Patients with schizophrenia show altered patterns of functional activation during working memory processing; specifically, high-performing patients appear to hyper-activate and low-performing patients appear to hypo-activate when compared with controls. It remains unclear how these individual differences in neurophysiological activation relate to the(More)
One of the most important considerations in any hypothesis based fMRI data analysis is to choose the appropriate threshold to construct the activation maps, which is usually based on p-values. However, in fMRI data, there are three factors which necessitate severe corrections in the process of estimating the p-values. First, the fMRI time series at an(More)