Rajesh Kumar

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PURPOSE To compare the performance of gonioscopy and anterior segment (AS) optical coherence tomography (OCT) in detecting angle closure in the different quadrants of the anterior chamber angle (ACA). DESIGN Cross-sectional observational study. PARTICIPANTS Five hundred two consecutive subjects more than 50 years of age with no previous ophthalmic(More)
Aggregation of amyloidogenic proteins is associated with several neurodegenerative diseases. Sequestration of misfolded and aggregated proteins into specialized deposition sites may reduce their potentially detrimental properties. Yeast exhibits a distinct deposition site for amyloid aggregates termed "Insoluble PrOtein Deposit (IPOD)", but nothing is known(More)
MicroRNAs (miRNAs) are small non-coding endogenous RNAs (18-24 nucleotides) which regulate gene expression at posttranscriptional level either by degrading the target mRNA (plants) or by blocking the protein translation through binding with 3' UTR of the target mRNA (animals). Though miRNAs are known to play key roles in animal development, miRNAs that are(More)
OBJECTIVE To report the 5-year progression to primary angle closure glaucoma (PACG) in a population-based cohort of primary angle closure (PAC) subjects. METHODS A total of 37 patients diagnosed as PAC during a population-based study in 1995 were invited for re-examination in 2000. Patients underwent a complete ophthalmic examination including ocular(More)
PURPOSE To evaluate the diagnostic capability of optical coherence tomography (Stratus OCT 3) for early glaucoma in Asian Indian eyes. DESIGN Cross-sectional observational study. PARTICIPANTS Two groups of patients (early glaucoma and normal) who satisfied the inclusion and exclusion criteria were included. Early glaucoma was diagnosed in presence of(More)
AIMS To evaluate the diagnostic ability of peripapillary vessel density measurements on optical coherence tomography angiography (OCTA) in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), and to compare these with peripapillary retinal nerve fibre layer (RNFL) thickness measurements. METHODS In a cross-sectional study, 48 eyes(More)
PURPOSE Approximately 10% of Chinese people older than 50 years in Singapore have asymptomatic narrow angles [also termed primary angle closure suspects (PACS)]. The aim of this study was to determine the attitudes and practices of ophthalmologists in Singapore regarding the management of these patients. METHODS A nation wide questionnaire-based survey(More)
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease(More)
OBJECTIVE To propose the Schwalbe line (SL) as a new anatomical landmark, independent of the scleral spur (SS) location, for assessing anterior chamber angle (ACA) width quantitatively with high-definition optical coherence tomography (HD-OCT). METHODS Study subjects underwent dark-room gonioscopy and HD-OCT in one randomly selected eye. The authors(More)