Rajendra Mohan Bhatt

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Genetic polymorphisms in diagnostic antigens are important factors responsible for variable performance of rapid diagnostic tests. Additionally, the failure of antigen expression due to gene deletion may also contribute to variable performance. We report Indian Plasmodium falciparum field isolates lacking both Pfhrp2 and Pfhrp3 genes leading to false(More)
Relapse pattern in P. vivax malaria was studied in five villages of Nadiad taluka, Kheda district, Gujarat. P. vivax cases treated with 600 mg chloroquine and in combination with 50 mg pyrimethamine (adult dose) yielded 28.31 and 27.73% relapse rate respectively. While relapse rate of 5.78% was observed with five day course of 75 mg primaquine (15 mg/day)(More)
Biology of malaria vectors were studied in Kheda district of central Gujarat in order to understand the vector behaviour in the wake of ecological changes. Anopheles culicifacies and An. stephensi were mainly endophilic whereas An. fluviatilis exhibited marked exophily. All the three vectors were predominantly zoophilic. Peak biting activity period of An.(More)
Studies on mosquito breeding in wells revealed the dominance of An. stephensi among the malaria vectors, whereas Cx. quinquefasciatus was most abundant in disused wells and was present in wells of all depths. None of the anopheline species was encountered when well depth up to water level exceeded 12 m. Larval breeding was effectively controlled through the(More)
A total of 41,552 anophelines comprising 16 species were collected during 70 all-night bovine-bait collection carried out in six villages of Kheda district, Gujarat. Anopheles subpictus, An. varuna, An. culicifacies, An. stephensi and An. vagus had unimodal biting rhythms. Most feeding occurred during the early night with occasional increase during(More)
Susceptibility/resistance to Plasmodium falciparum malaria has been correlated with polymorphisms in more than 30 human genes with most association analyses having been carried out on patients from Africa and south-east Asia. The aim of this study was to examine the possible contribution of genetic variants in the TNF and FCGR2A genes in determining(More)
BACKGROUND & OBJECTIVES Two bacterial larvicide (bio-larvicide) formulations--Bacticide and VectoBac containing viable endospores and delta endotoxin of Bacillus thuringiensis var israelensis H-14 were evaluated in 2001 for their mosquito larvicidal efficacy under the operational conditions of urban malaria control programme in Surat city, India. METHODS(More)
OBJECTIVE To describe India's National Antimalarial Drug Resistance Monitoring System, measure the efficacy of first-line malaria treatments, and determine risk factors for treatment failure. METHODS In 2009-2010, prospective studies with 28 days of follow-up were conducted at 25 sentinel sites. Patients infected with Plasmodium falciparum were given(More)
783 blood samples for the study of distribution of ABO blood groups and sickle cell haemoglobin in relation to malaria, from both the sexes of Muslim and Christian populations of Kheda district were screened. 414 blood samples from male individuals were screened for G-6-PD deficiency. High frequency of G-6-PD deficiency was observed in Christians (5.9%) and(More)
Knockdown resistance in insects resulting from mutation(s) in the voltage gated Na+ channel (VGSC) is one of the mechanisms of resistance against DDT and pyrethroids. Recently a point mutation leading to Leu-to-Phe substitution in the VGSC at residue 1014, a most common kdr mutation in insects, was reported in Anopheles culicifacies-a major malaria vector(More)