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Interleukin-22 (IL-22) is central to host protection against bacterial infections at barrier sites. Both innate lymphoid cells (ILCs) and T cells produce IL-22. However, the specific contributions of… Expand
Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) and CD4+ inducible regulatory T cells (iTreg cells) emerge from an overlapping developmental program. In the intestines, the vitamin A… Expand
Discovery of the T-helper 17 (Th17) subset heralded a major shift in T-cell biology and immune regulation. In addition to defining a new arm of the adaptive immune response, studies of the Th17… Expand
After emerging from the thymus, naive CD4 T cells circulate through secondary lymphoid tissues, including gut-associated lymphoid tissue of the intestine. The activation of naïve CD4 T cells by… Expand
The inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due to an ill-defined immune-dysfunction.… Expand
RORγt, a retinoid orphan nuclear receptor and the master transcription factor of the Th17 subset of CD4+T helper cells, is one of the most promising targets to treat a host of autoimmune diseases.… Expand