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Of an original cohort of 39 epileptic patients, 28 were observed for a median of 26.5 months after an initial psychiatric interview. As had been noted in the original cohort, treatment with phenobarbital, as compared with treatment with carbamazepine or no anticonvulsant, was associated with higher rates of depression (38% vs 0%, P = .04). Depression… (More)
Methyl-p-hydroxyphenyllactate (MeHPLA) is a bioflavonoid and/or tyrosine metabolite which may regulate cellular growth and proliferation through interactions with nuclear type II sites. Our current studies suggest that type II sites may function as MeHPLA receptors which are localized on the nuclear matrix, and occupancy of this binding site by MeHPLA… (More)
Ocular blood flow and retinal function were determined in this study with colored microspheres and b-wave amplitude of electroretinography, respectively. It was found that N-nitropyrazole analogs can facilitate the retinal function recovery efficiently after ischemic insult primarily through increase of choroidal blood flow specifically. Since age-related… (More)
Preliminary antiviral, antibacterial, and antifungal screening results of a series of isatin N-Mannich bases are provided.
Previous studies in our laboratory demonstrated that methyl p-hydroxyphenyllactate (MeHPLA) is an important cell growth-regulating agent which binds to nuclear type II binding sites in normal and malignant cells. Furthermore, this compound is deficient in a variety of rat and mouse mammary tumors and human breast cancer preparations, and this deficiency… (More)
[reactions: see text] An expeditious, solvent-free, and high yield conversion of ketones, flavones, isoflavones, lactones, amides, and esters to the corresponding thio analogues is described utilizing Lawesson's reagent in a process that circumvents the use of dry solvents and excess of the reagent.
We have recently demonstrated that methyl p-hydroxyphenyllactate (MeHPLA) is the endogenous ligand for nuclear type II binding sites in the rat uterus and other estrogen target and non-target tissues. MeHPLA binds to nuclear type II binding sites with a very high binding affinity (Kd approximately 4-5 nM), blocks uterine growth in vivo, and inhibits MCF-7… (More)
A number of vanillic acid analogues (1-14) have been synthesised and evaluated against experimental filarial infections using cotton rats (Sigmodon hispidus) infected with Litomosoides carinii, a primary screening model, at a dose of 30 mg/kg, ip for 5 days. Of the 8 compounds tested, 4 (5,7, 11 and 12) exhibited high micro- and macro-filaricidal activity… (More)