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Tenofovir treatment of primary osteoblasts alters gene expression profiles: implications for bone mineral density loss.
There is strong clinical evidence that implicates tenofovir in the loss of bone mineral density during treatment of human immunodeficiency virus infection. In this study, we sought to test theExpand
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HDAC3 and HDAC7 Have Opposite Effects on Osteoclast Differentiation*
Histone deacetylases (HDACs) are negative regulators of transcription. Endochondral bone formation including chondrocyte and osteoblast maturation is regulated by HDACs. Very little is known aboutExpand
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  • Open Access
Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts.
Clinical observations have implicated the antiretroviral drug tenofovir with bone density loss during the management of HIV infection. The goal of this study was to investigate the in vitro effectsExpand
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Tenofovir-associated bone density loss
Clinical observations have revealed a strong correlation between loss of bone density in HIV-infected individuals, particularly in conjunction with the antiretroviral drug tenofovir, a nucleotideExpand
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  • Open Access
Bone Morphogenetic Proteins Signal Via SMAD and Mitogen-activated Protein (MAP) Kinase Pathways at Distinct Times during Osteoclastogenesis*
Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclastsExpand
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Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease.
BACKGROUND The CXC chemokine receptor 4 (CXCR4) and its ligand, stromal cell-derived factor-1 (SDF-1alpha or CXC chemokine ligand 12) are involved in the trafficking of leukocytes into and out ofExpand
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Metastasizing pleomorphic adenoma presents intraorally: a case report and review of the literature.
Pleomorphic adenoma (PA), also known as mixed tumor, is the most common benign salivary gland neoplasm, characterized histologically by both epithelial and mesenchymal elements. Approximately 75% ofExpand
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  • Open Access
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma
BackgroundBone morphogenetic protein (BMP) signaling is thought to play key roles in regulating the survival and maintenance of cancer stem cells (CSCs), which contribute to disease recurrences andExpand
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Smad1/5 and Smad4 Expression Are Important for Osteoclast Differentiation
To investigate the necessity of the canonical BMP pathway during osteoclast differentiation, we created osteoclasts with a conditional gene deletion for Smad1 and Smad5 (SMAD1/5), or Smad4 usingExpand
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Methionine restriction alters bone morphology and affects osteoblast differentiation
Methionine restriction (MR) extends the lifespan of a wide variety of species, including rodents, drosophila, nematodes, and yeasts. MR has also been demonstrated to affect the overall growth of miceExpand
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