Raj Mohan Nambiar

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ERM (ezrin, radixin moesin) proteins in lymphocytes link cortical actin to plasma membrane, which is regulated in part by ERM protein phosphorylation. To assess whether phosphorylation of ERM proteins regulates lymphocyte migration and membrane tension, we generated transgenic mice whose T-lymphocytes express low levels of ezrin phosphomimetic protein(More)
The prevalence of protein calorie malnutrition (PCM) based on ten nutritional parameters was studied in 307 patients undergoing major elective surgical operations. These parameters included anthropometric measurements (weight/height, triceps skin fold thickness, arm muscle circumference) and biochemical (serum total proteins, albumin, transferrin,(More)
Singapore is a small island republic in South East Asia with a population of approximately 3.5 million people, of which residents make up nearly 90%. Of these, 77.7% are Chinese; 14.1%, Malays; 7.1%, Indians; and 1.8%, other ethnic groups. The overall ratio of males to females is 1026 :1000, with a slightly higher male preponderance in Indians. Since the(More)
Adenocarcinoma in association with chronic anal fistula is a rare disease entity with a male preponderence in most reported series. The patient typically presents with a long history of perianal disease. Diagnosis is often delayed because of failure to obtain biopsy evidence of the condition. A chronic anal fistula may become malignant. However, despite(More)
Intraoperative colonic irrigation followed by one-stage resection is gaining popularity as the optimal surgical treatment for left-sided colonic obstruction. However, its efficacy and potential hazards have not been adequately tested in obstruction due to colonic cancer. We analyzed the early results of 23 consecutive patients with obstructive left-sided(More)
Forty-five patients with various malignancies of the gastrointestinal tract had their nutritional status assessed pre-operatively to determine the prevalence of malnutrition and to establish the correlation of malnutrition with post-operative outcome. Ten nutritional parameters were assessed. Based on these markers, we found a significant degree of(More)
The outcome of 51 patients who underwent gastrojejunostomy for unresectable gastric cancer with outlet obstruction was studied to evaluate the palliative benefit. The operative mortality and postoperative complication rates were 22% and 55% respectively. The mean duration of postoperative hospital stay was 13 days and median survival period 14 weeks.(More)
Isolated splenic abscess is an uncommon condition. Seven cases seen between 1980 and 1990 are reviewed. The clinical presentation is non-specific and diagnosis is usually delayed. Computerized tomography allowed for accurate diagnosis in all cases. Pseudomonas species as a causative organism is reported to be rare, but were present in three of the present(More)
The objective of this study was to determine whether or not whole bowel irrigation through oral route was a safe and acceptable alternative to traditional bowel washout per rectum in preparation for large bowel surgery. Out of a total of 114 patients, 32 had whole bowel irrigation, 71 had traditional washout and 11 had no bowel preparation. The irrigation(More)
PC: The Academy of Medicine was established during a very different time. How far do you think it has fulfilled its original aims? Moving forward, what do you think would be the continuing role of the Academy? RN: When it was established in the 1950s, the Academy’s main aims were to advance postgraduate medical education, research and promote high standards(More)