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Fluorescence microscopic analysis of newly replicated DNA has revealed discrete granular sites of replication (RS). The average size and number of replication sites from early to mid S-phase suggest that each RS contains numerous replicons clustered together. We are using fluorescence laser scanning confocal microscopy in conjunction with multidimensional(More)
Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a(More)
simulators [9]. There are two main ways of obtaining a DR of a real world object. One is by acquisition with a This paper presents the properties of the discrete analytical hyperplanes. They are defined analytically in the discrete do-physical device like a camera for a 2D DR, a CT or MR main by Diophantine equations. We show that the discrete scanner for a(More)
The introduction of advanced imaging technologies has improved significantly the quality of medical care available to patients. Non-invasive imaging modalities allow a physician to make increasingly accurate diagnoses and render precise and measured modes of treatment. Current uses of imaging technologies include laboratory medicine, surgery, radiation(More)
A viral population can contain a large and diverse collection of viral haplotypes which play important roles in maintaining the viral population. We present an algorithm for reconstructing viral haplotypes in a population from paired-end Next Generation Sequencing (NGS) data. We propose a novel polynomial time dynamic programming based approximation(More)
MOTIVATION Arrays allow measurements of the expression levels of thousands of mRNAs to be made simultaneously. The resulting data sets are information rich but require extensive mining to enhance their usefulness. Information theoretic methods are capable of assessing similarities and dissimilarities between data distributions and may be suited to the(More)
To study when and where active genes replicated in early S phase are transcribed, a series of pulse-chase experiments are performed to label replicating chromatin domains (RS) in early S phase and subsequently transcription sites (TS) after chase periods of 0 to 24 h. Surprisingly, transcription activity throughout these chase periods did not show(More)
The results of this study indicate that automated alignment of pairs of radiographs produces subtractions that are indistinguishable in quality from subtractions aligned manually by an experienced aligner. In developing the algorithm for automated alignment, care was taken that the criteria used for establishing a window appropriate for testing the quality(More)