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To characterize anisotropic water diffusion in brain white matter, a theoretical framework is proposed that combines hindered and restricted models of water diffusion (CHARMED) and an experimental methodology that embodies features of diffusion tensor and q-space MRI. This model contains a hindered extra-axonal compartment, whose diffusion properties are(More)
Knowledge of microstructural features of nerve fascicles, such as their axon diameter, is crucial for understanding normal function in the central and peripheral nervous systems as well as assessing changes due to pathologies. In this study double-pulsed field gradient (d-PFG) filtered MRI was used to map the average axon diameter (AAD) in porcine spinal(More)
One aim of this work is to investigate the feasibility of using a hierarchy of models to describe diffusion tensor magnetic resonance (MR) data in fixed tissue. Parsimonious model selection criteria are used to choose among different models of diffusion within tissue. Using this information, we assess whether we can perform simultaneous tissue segmentation(More)
In this work we investigate the feasibility and effectiveness of unsupervised tissue clustering and classification algorithms for DTI data. Tissue clustering and classification are among the most challenging tasks in DT image analysis. While clus­ tering separates acquired data into objects, tissue classifica­ tion provides in-depth information about each(More)
The primary aim of this work is to propose and investigate the effectiveness of a novel unsupervised tissue clustering and classification algorithm for diffusion tensor MRI (DTI) data. The proposed algorithm utilizes information about the degree of homogeneity of the distribution of diffusion tensors within voxels. We adapt frameworks proposed by Hext and(More)
Quantitative assessment of perfusion defects with myocardial contrast echocardiography can be a valuable tool in the evaluation of patients with coronary artery disease. However, the use of 2-dimensional echocardiography for this purpose is limited to a restricted number of imaging planes. Real-time 3-dimensional echocardiography (RT3D) is a novel technique(More)
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