Rainer de Martin

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We present the second and improved release of the TOUCAN workbench for cis-regulatory sequence analysis. TOUCAN implements and integrates fast state-of-the-art methods and strategies in gene regulation bioinformatics, including algorithms for comparative genomics and for the detection of cis-regulatory modules. This second release of TOUCAN has become open(More)
By differential screening of tumor necrosis factor ␣ (TNF-␣) and lipopolysaccharide (LPS)-activated endothelial cells (ECs), we have identified a cDNA clone that turned out to be a member of the inhibitor of apoptosis (iap) gene family. iap genes function to protect cells from undergoing apoptotic death in response to a variety of stimuli. These iap genes,(More)
OBJECTIVE Endothelial cells comprise a key component of the inflammatory response. We set out to obtain a comprehensive overview of the immediate-early to early gene expression program of interleukin-1 (IL-1)-stimulated endothelial cells and to identify novel transcription factors and regulatory elements. METHODS AND RESULTS Human umbilical vein(More)
  • Martina Hoeth, Heide Niederleithner, Renate Hofer-Warbinek, Martin Bilban, Herbert Mayer, Ulrike Resch +5 others
  • 2012
BACKGROUND Mutations in the transcription factor SOX18 are responsible for specific cardiovascular defects in humans and mice. In order to gain insight into the molecular basis of its action, we identified target genes of SOX18 and analyzed one, MMP7, in detail. METHODOLOGY/PRINCIPAL FINDINGS SOX18 was expressed in HUVEC using a recombinant adenoviral(More)
  • Sabine Kopf, Katharina Viola, Atanas G. Atanasov, Kanokwan Jarukamjorn, Lucie Rarova, Nicole Kretschy +18 others
  • 2013
Metastases destroy the function of infested organs and are the main reason of cancer-related mortality. Heteronemin, a natural product derived from a marine sponge, was tested in vitro regarding its properties to prevent tumour cell intravasation through the lymph-endothelial barrier. In three-dimensional (3D) cell cultures consisting of MCF-7 breast cancer(More)
  • Katharina Viola, Sabine Kopf, Lucie Rarova, Kanokwan Jarukamjorn, Nicole Kretschy, Mathias Teichmann +17 others
  • 2013
Health beneficial effects of xanthohumol have been reported, and basic research provided evidence for anti-cancer effects. Furthermore, xanthohumol was shown to inhibit the migration of endothelial cells. Therefore, this study investigated the anti-metastatic potential of xanthohumol. MCF-7 breast cancer spheroids which are placed on lymphendothelial cells(More)
  • Stefan Stojkovic, Christoph Kaun, Jose Basilio, Sabine Rauscher, Lena Hell, Konstantin A. Krychtiuk +11 others
  • 2016
Tissue factor (TF) is the primary trigger of coagulation. Elevated levels of TF are found in atherosclerotic plaques, and TF leads to thrombus formation when released upon plaque rupture. Interleukin (IL)-33 was previously shown to induce angiogenesis and inflammatory activation of endothelial cells (ECs). Here, we investigated the impact of IL-33 on TF in(More)
  • Birgit Kreiseder, Yvonne M Holper-Schichl, Barbara Muellauer, Nico Jacobi, Alexander Pretsch, Johannes A. Schmid +4 others
  • 2015
Melanoma is the most dangerous type of skin cancer accounting for 48,000 deaths worldwide each year and an average survival rate of about 6-10 months with conventional treatment. Tumor metastasis and chemoresistance of melanoma cells are reported as the main reasons for the insufficiency of currently available treatments for late stage melanoma. The(More)
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