Rainer Sundmacher

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BACKGROUND/AIM Advanced donor age, long death to excision time interval, and factors related to organ culture can trigger unfavourable intracellular processes in the graft endothelium and contribute to chronic endothelial cell loss after penetrating keratoplasty. The aim of this study was to investigate factors influencing chronic endothelial cell loss in a(More)
• Background: It was the purpose of this retrospective study to evaluate the effect of a preoperative history of glaucoma on graft survival after penetrating keratoplasty. • Patients and methods: Six hundred and forty-six penetrating keratoplasties with generally good prognosis were analyzed retrospectively. Indications for surgery were corneal dystrophy,(More)
BACKGROUND Graft-prognosis after penetrating high-risk keratoplasty has improved considerably with the use of systemic immunosuppressive medications. In this retrospective investigation we analyzed the long-term results of 417 high-risk keratoplasties with systemic immunosuppression (cyclosporine A [CsA] or mycophenolate mofetil [MMF]). METHODS A total of(More)
BACKGROUND/AIMS The requirement for an effective, minimally toxic immunosuppressive agent remains a major obstacle to performing high risk corneal transplantation. Although therapy with cyclosporin A (CSA) allows superior graft survival, its use is limited because of a wide range of side effects. Mycophenolate mofetil (MMF) has been shown to be a safe and(More)
OBJECTIVE Chronic endothelial cell loss of the graft is very common after penetrating keratoplasty. The aetiology of this is unknown. Clinically, non-identifiable immune reactions have been suspected. Recently, we were able to demonstrate that proper human leucocyte antigen (HLA) matching is a suitable means to reduce classical immune reactions in normal(More)
• Background: It was the purpose of this study to compile the results of all high-risk keratoplasties (kp) performed in our hospital under systemic ciclosporin A (Ci A) cover from 1987 through 1994. • Methods: One hundred and thirty-one keratoplasties were performed. Ci A was administered for an average period of 9.4 months. We aimed at trough levels of(More)
PURPOSE Lymphocytes, monocytes, and macrophages are the predominating immune cells in graft rejection after keratoplasty in animal models. This study focuses on the isolation of immune cells from the anterior chamber of patients with slight, moderate, and severe endothelial immune reactions after penetrating keratoplasty. METHODS Anterior chamber puncture(More)
BACKGROUND The aim of this study was to compare immunologic graft rejection in adult and 3-week-old immature recipients in the rat keratoplasty model. METHODS Forty orthotopic penetrating keratoplasties were performed in four different donor-recipient combinations. Group 1 consisted of adult Fisher donors and adult Lewis recipients, group 2 consisted of(More)
Hintergrund. In der Vergangenheit konnten wir mit Einsatz der elektronischen intraokularen Nadeldruckmessung zeigen, dass die Applanationstonometrie bei pathologischen Hornhäuten ganz überwiegend falsch niedrige Werte liefert. Ziel dieser Studie war es zu untersuchen, ob bei diesen Hornhäuten die Impressions-Tonometrie genauere Ergebnisse liefert, als die(More)
Der Ophthalmologe 2•2000 Rezidivierenden Erosiones nach mechanischen Traumata, bei epithelialen Basalmembrandystrophien und idiopathischer Genese liegt möglicherweise ein in seinen Auswirkungen ähnlicher epithelialer Stoffwechseldefekt zugrunde, der die Produktion einer minderwertigen Basalmembran bedingt. Hierdurch wird die optimale Haftung des Epithels(More)