Rainer Schindler

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Hepatic retinyl ester hydrolase (REH) activity was isolated from porcine and human liver and characterized, and some of its properties were compared with those of other retinyl-ester-splitting enzymes. Sequence analysis revealed that the REH proteins are structurally similar to non-specific carboxylesterases and distinct from bile salt-activated lipases and(More)
Neoangiogenesis is required for tumor development and progression. Many solid tumors induce vascular proliferation by production of angiogenic factors, prominently vascular endothelial growth factor (VEGF). Because nutrition is a causative factor for tumor prevention and promotion, we determined whether secondary plant constituents, i.e., flavonoids,(More)
The transmembrane protein CD16 (Fc gamma RIII) is detected on activated macrophages, natural killer (NK) cells and a small subset of T lymphocytes. From CD3-CD56+ CD16+bright NK cells and CD3+ CD56+ CD16+dim non-major histocompatibility complex (MHC)-restricted cytotoxic T lymphocyte (CTL) clones were generated reflecting the stable, but different, CD16(More)
Three common micromethods for vitamin A1 determination were applied to blood, and compared with each other. Methods under investigation were: silicic acid column technique described by Pollack et al [16], HPLC procedure published by de Ruyter and de Leenheer [6, 7] and correction formula method according to Thompson et al [20]. The serum levels of vitamin A(More)
The transport of retinyl palmitate in postabsorptive human blood has been investigated. For this purpose, lipoproteins were isolated from fasting serum of normal subjects as well as of patients with various diseases. The serum retinyl palmitate values of these individuals ranged from 2.0-30.3 micrograms/100 ml, with a mean value of 7.6 micrograms/100 ml. In(More)
Postmortem livers from 77 "normal" persons, 37 patients with neoplastic disease, 10 subjects with liver insufficiency, and 7 infants were analysed for free and esterified retinol. The average concentrations of total vitamin A for the members of each group were 597, 551, 289, and 162 micrograms/g wet liver, respectively. Compared with corresponding control(More)