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BACKGROUND WHO case management guidelines for severe pneumonia involve referral to hospital for treatment with parenteral antibiotics. If equally as effective as parenteral treatment, home-based oral antibiotic treatment could reduce referral, admission, and treatment costs. Our aim was to determine whether home treatment with high-dose oral amoxicillin and(More)
BACKGROUND AND AIMS Using current WHO guidelines, children with wheezing are being over prescribed antibiotics and bronchodilators are underutilised. To improve the WHO case management guidelines, more data is needed about the clinical outcome in children with wheezing/pneumonia overlap. METHODOLOGY In a multicentre prospective study, children aged 1-59(More)
OBJECTIVE To evaluate whether five days' treatment with injectable ampicillin plus gentamicin compared with chloramphenicol reduces treatment failure in children aged 2-59 months with community acquired very severe pneumonia in low resource settings. DESIGN Open label randomised controlled trial. SETTING Inpatient wards within tertiary care hospitals in(More)
BACKGROUND world Health Organization (WHO) acute respiratory illness case management guidelines classify children with fast breathing as having pneumonia and recommend treatment with an antibiotic. There is concern that many of these children may not have pneumonia and are receiving antibiotics unnecessarily. This could increase antibiotic resistance in the(More)
INTRODUCTION WHO pneumonia case management guidelines recommend oral amoxicillin as first line treatment for non-severe pneumonia. Increasing treatment failure rates have been reported over a period of time, which could possibly be due to increasing minimum inhibitory concentrations of Streptococcus pneumoniae and Haemophilus influenzae for amoxicillin.(More)
SETTING In the recent past, there have been reports of rising treatment failure rates for non-severe pneumonia. It is felt that World Health Organization (WHO) criteria for therapy failure are too sensitive and that many children are unnecessarily classified as failures. We studied alternative, less sensitive therapy failure criteria. METHODS In this(More)
BACKGROUND Wheeze is a significant problem in children. There is a gradual trend of switching from oral to inhaled bronchodilator therapy. No randomised trials have been carried out in the community to compare the clinical outcome of two modes of therapy. If outcome with oral and inhaled bronchodilators is the same in young wheezers in developing countries,(More)
OBJECTIVE To compare the frequencies and clinical features of diarrheal versus non-diarrheal presentation of celiac disease (CD). STUDY DESIGN Cross-sectional study. PLACE AND DURATION OF STUDY Paediatric Department, Benazir Bhutto Hospital, Rawalpindi, from January to December 2013. METHODOLOGY Children with celiac disease, newly diagnosed on the(More)
OBJECTIVE To determine the accuracy of anti-tissue transglutaminase IgA (TTG) antibody titer in the diagnosis of celiac disease, taking small intestine histopathology as the gold standard. STUDY DESIGN Cross-sectional analytical study. PLACE AND DURATION OF STUDY Department of Paediatrics, Benazir Bhutto Hospital, Rawalpindi, from February to July 2013.(More)
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