Learn More
We employed a pH-sensitive GFP analog, superecliptic phluorin, to observe aspects of nicotinic acetylcholine receptor (nAChR) trafficking to the plasma membrane (PM) in cultured mouse cortical neurons. The experiments exploit differences in the pH among endoplasmic reticulum (ER), trafficking vesicles, and the extracellular solution. The data confirm that(More)
Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson's disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is(More)
This paper puts forward a new efficient construction for Multi-Receiver Signcryption in the Identity-based setting. We consider a scenario where a user wants to securely send a message to a dynamically changing subset of the receivers in such a way that non-members of the of this subset cannot learn the message. The obvious solution is to transmit an(More)
The acronym SePhaChARNS, for "selective pharmacological chaperoning of acetylcholine receptor number and stoichiometry," is introduced. We hypothesize that SePhaChARNS underlies classical observations that chronic exposure to nicotine causes "upregulation" of nicotinic receptors (nAChRs). If the hypothesis is proven, (1) SePhaChARNS is the molecular(More)
—Group Key Establishment is fundamental for a variety of security mechanisms in group applications. It allows n ≥ 2 principals to agree upon a common secret key. This can further be classified into Group Key Exchange (or Group Key Agreement), where all the principals participate in the construction of the key, and Group Key Transport (or Group Key(More)
The up-regulation of α4β2* nicotinic acetylcholine receptors (nAChRs) by chronic nicotine is a cell-delimited process and may be necessary and sufficient for the initial events of nicotine dependence. Clinical literature documents an inverse relationship between a person's history of tobacco use and his or her susceptibility to Parkinson's disease; this may(More)
We report the first observation that endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) can decrease when a central nervous system drug acts as an intracellular pharmacological chaperone for its classic receptor. Transient expression of α4β2 nicotinic receptors (nAChRs) in Neuro-2a cells induced the nuclear translocation of activating(More)
α6* nicotinic acetylcholine receptors (nAChRs) are highly expressed in mesostriatal and nigrostriatal dopaminergic systems, and participate in motor control, reward, and learning and memory. In vitro functional expression of α6* nAChRs is essential for full pharmacological characterization of these receptors and for drug screening, but has been challenging.(More)
  • Rahul Srinivasan, Rigo Pantoja, Fraser J. Moss, Elisha D.W. Mackey, Cagdas D. Son, Julie Miwa +1 other
  • 2011
Repeated or chronic exposure to nicotine—beyond the seconds and minutes that lead to receptor activation and/or desensitization—is essential for nicotine depen-Chronic exposure also apparently underlies the inverse correlation between a person's history of tobacco use and his or her susceptibility to Parkinson's disease (Ritz et al., 2007). Literature since(More)