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This paper explores a novel way to incorporate hardware-programmable resources into a processor microarchitecture to improve the performance of general-purpose applications. Through a coupling of compile-time analysis routines and hardware synthesis tools, we automatically configure a given set of the hardware-programmable functional units (PFUs) and thus(More)
Parametric process variations, which are inherent in the manufacture of complex digital circuits, can cause variations in the timing characteristics of a digital device. These device timing variations can cause catastrophic failures to the intended logical operation of the whole design. Min-Max Timing Simulation is a simulation technique which is well(More)
In this paper, a general methodology for design rule development and the CAD tool which implements this methodology, Statistical Design Rule Developer (STRUDEL), are presented. The focus of the proposed approach is the concept of a statistical design rule, which is defined as a geometric design rule with an associated probability of failure. Global lateral(More)
The study describes the kinetics of demethylation of mononitrosocaffeidine (MNC), a new asymmetric N-nitrosamine derived from caffeine. The demethylation of its precursor compound caffeidine was also studied. The results presented here suggest (a) that liver microsomes from fasted rats preferentially demethylate the N-methylnitrosamine group in MNC(More)
Mutagenesis in S. typhimurium and in vitro induction of DNA single-strand breaks in primary rat hepatocytes (DNA-SSB) have been investigated for two new N-nitroso compounds, mononitrosocaffeidine (MNC) and dinitrosocaffeidine (DNC). Mononitrosamidocaffeidine (MNAC) and tert.-(butyloxy)carbonyl-mononitrosamidocaffeidine (t-BOC-MNAC), both nitrosated(More)