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- T. K. Shajahan, Alok Ranjan Nayak, Rahul Pandit
- PloS one
- 2009

Regular electrical activation waves in cardiac tissue lead to the rhythmic contraction and expansion of the heart that ensures blood supply to the whole body. Irregularities in the propagation of these activation waves can result in cardiac arrhythmias, like ventricular tachycardia (VT) and ventricular fibrillation (VF), which are major causes of death in… (More)

- Subhasis Sinha, Amit Pande, Rahul Pandit
- Physical review letters
- 2001

Ventricular fibrillation, the major reason behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular disturbances in the spatiotemporal electrical activation of the heart make it incapable of any concerted pumping action. Methods of controlling ventricular fibrillation include electrical defibrillation as well as… (More)

- Anthony Stuart Mclean, Stephen Joseph Huang, +6 authors Ian Mark Seppelt
- Critical care medicine
- 2007

OBJECTIVE
To investigate the changes in B-type natriuretic peptide concentrations in patients with severe sepsis and septic shock and to investigate the value of B-type natriuretic peptide in predicting intensive care unit outcomes.
DESIGN
Prospective observational study.
SETTING
General intensive care unit.
PATIENTS
Forty patients with severe sepsis… (More)

- Rupamanjari Majumder, Alok Ranjan Nayak, Rahul Pandit
- PloS one
- 2012

We present a comprehensive numerical study of spiral- and scroll-wave dynamics in a state-of-the-art mathematical model for human ventricular tissue with fiber rotation, transmural heterogeneity, myocytes, and fibroblasts. Our mathematical model introduces fibroblasts randomly, to mimic diffuse fibrosis, in the ten Tusscher-Noble-Noble-Panfilov (TNNP) model… (More)

- T. K. Shajahan, Sitabhra Sinha, Rahul Pandit
- Physical review. E, Statistical, nonlinear, and…
- 2007

Every sixth death in industrialized countries occurs because of cardiac arrhythmias such as ventricular tachycardia (VT) and ventricular fibrillation (VF). There is growing consensus that VT is associated with an unbroken spiral wave of electrical activation on cardiac tissue but VF with broken waves, spiral turbulence, spatiotemporal chaos and rapid,… (More)

- Alok Ranjan Nayak, T. K. Shajahan, Alexander V. Panfilov, Rahul Pandit
- PloS one
- 2013

Cardiac fibroblasts, when coupled functionally with myocytes, can modulate the electrophysiological properties of cardiac tissue. We present systematic numerical studies of such modulation of electrophysiological properties in mathematical models for (a) single myocyte-fibroblast (MF) units and (b) two-dimensional (2D) arrays of such units; our models build… (More)

Sudden cardiac death is often caused by cardiac arrhythmias. Recently, special attention has been given to a certain arrhythmogenic condition, the long-QT syndrome, which occurs as a result of genetic mutations or drug toxicity. The underlying mechanisms of arrhythmias, caused by the long-QT syndrome, are not fully understood. However, arrhythmias are often… (More)

Early afterdepolarizations (EADs), which are abnormal oscillations of the membrane potential at the plateau phase of an action potential, are implicated in the development of cardiac arrhythmias like Torsade de Pointes. We carry out extensive numerical simulations of the TP06 and ORd mathematical models for human ventricular cells with EADs. We investigate… (More)

- Alok Ranjan Nayak, Rahul Pandit
- Physical review. E, Statistical, nonlinear, and…
- 2015

We study the dynamical behaviors of two types of spiral- and scroll-wave turbulence states, respectively, in two-dimensional (2D) and three-dimensional (3D) mathematical models, of human, ventricular, myocyte cells that are attached to randomly distributed interstitial fibroblasts; these turbulence states are promoted by (a) the steep slope of the… (More)

- Alok Ranjan Nayak, Alexander V. Panfilov, Rahul Pandit
- Physical review. E
- 2017

We present systematic numerical studies of the possible effects of the coupling of human endocardial and Purkinje cells at cellular and two-dimensional tissue levels. We find that the autorhythmic-activity frequency of the Purkinje cell in a composite decreases with an increase in the coupling strength; this can even eliminate the autorhythmicity. We… (More)