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OBJECTIVES We compared the safety, tolerance and effectiveness of overdrive high right atrial (RA), dual-site RA and support (DDI or VDI) pacing (SP) in patients with symptomatic atrial fibrillation (AF) and bradycardias. BACKGROUND Optimal pacing methods for AF prevention remain unclear. METHODS Patients (n = 118) were randomized to each of three(More)
OBJECTIVES We investigated 1) the feasibility, safety and efficacy of multisite right atrial pacing for prevention of atrial fibrillation (AF); and 2) the ability of atrial pacing in single- and dual-site modes to increase arrhythmia-free intervals in patients with drug-refractory AF. BACKGROUND We recently developed and applied a novel technique of(More)
Isochronal maps of ventricular activation were analyzed in dogs 3-5 days after ligation of the left anterior descending coronary artery utilizing a 64-channel multiplexer. Isochronal maps of the effective refractory period were determined from 62 epicardial sites and correlated with the activation maps. The ischemia occurring in the surviving epicardial(More)
BACKGROUND The ability of intermittent or symptom-based monitoring to accurately identify patients with atrial tachycardia/atrial fibrillation (AT/AF) and to quantify AT/AF burden is not well established. OBJECTIVES The purpose of this study was to compare intermittent and symptom-based monitoring to continuous monitoring for (1) identification of(More)
INTRODUCTION Radiofrequency ablation is successful for treating some arrhythmias but not for CAD-VT, possibly due to insufficient lesion size. Irrigated electrodes were developed to apply higher power for longer duration to create larger lesions. Our objective was to characterize and compare irrigated and standard ablation in terms of lesion size, crater,(More)
INTRODUCTION This study evaluated the safety and efficacy of a new dual-chamber implantable cardioverter defibrillator (ICD) to detect and treat atrial tachyarrhythmias in patients with drug-refractory atrial fibrillation (AF) and no indication for a ventricular ICD. METHODS AND RESULTS A dual-chamber ICD (Medtronic 7250 Jewel AF) was implanted in 144 of(More)
BACKGROUND Approximately 25% of patients who receive an implantable cardioverter-defibrillator (ICD) to treat ventricular tachyarrhythmias have documented atrial tachyarrhythmias before implantation. This study assessed the ability of device-based prevention and termination therapies to reduce the burden of spontaneous atrial tachyarrhythmias. METHODS AND(More)
Both sustained and nonsustained ventricular tachycardias were reproducibly induced in dogs 3 to 5 days after ligation of the left anterior descending coronary artery. Isochronal maps of ventricular activation were constructed from close bipolar electrograms recorded from the entire epicardial surface and selected intramural sites by a computerized(More)
BACKGROUND A unipolar defibrillation system using a single right ventricular (RV) electrode and the active shell or "CAN" of the implantable cardioverter-defibrillator itself situated in a left infraclavicular pocket has been shown to be as efficient in defibrillation as an epicardial lead system. The purpose of this study was to determine whether(More)
OBJECTIVES We tested the ability of dual-site right atrial pacing to prevent atrial fibrillation (AF) or atrial flutter induced by single-site atrial pacing and correlated its efficacy with clinical patient characteristics, atrial activation times and refractory periods. BACKGROUND Prevention of recurrent AF with long-term dual-site right atrial pacing(More)