Rahul D. Kamble

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In the present communication, a simple and efficient synthesis of some new Pyrano-[2,3-c]-pyrazoles derivatives are described by the one-pot condensation of a mixture of 3-methyl-1-phenyl-1H-pyrazole-5(4H)-one, substituted heterylaldehydes and malononitriles in polyethylene glycol (PEG-400) as green reaction solvent, further reacted with substituted(More)
Now a days, cloud computing is most popular network in world. Cloud computing provides resource sharing and online data storage for the end users. In existed cloud computing systems there are many security issues. So, security becomes essential part for the data which is stored on cloud. To solve this problem we have proposed this paper. This paper presents(More)
Synthesis of novel thiophene substituted isoxazoline libraries is currently of high interest. Here, we have reported detailed syntheses of 2,5-dichlorothiophene, 5-chloro-2-(benzylthio)thiophene, and 5-chlorothiophene-2-sulphonamide substituted analogs of isoxazoline from chalcones catalyzed by NaOH in PEG-400 as green solvent. In vitro antimycobacterial(More)
In the midst of increasing multidrug resistance and the growing incidence of infections of Mycobacterium tuberculosis, there is compelling evidence for the synthesis of novel and effective anti-tuberculosis agents. In this report, we have synthesized, characterized, and evaluated benzo[1,3]oxazine derivatives as growth inhibitors of M. tuberculosis. Among(More)
OBJECTIVES The present subacute study was designed to evaluate the effect of coenzyme Q 10 (CoQ10) in the 28 days aroclor 1254 exposure induced oxidative stress in mice brain. METHODS Biochemical estimations of brain lipid peroxidation (LPO), reduced glutathione (GSH), and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase(More)
Searching novel, safe and effective anti-inflammatory agents has remained an evolving research enquiry in the mainstream of inflammatory disorders. In the present investigation series of thiazoles bearing pyrazole as a possible pharmacophore were synthesized and assessed for their anti inflammatory activity using in vitro and in vivo methods. In order to(More)
A new series of dihydro-1H-pyrazolo[3,4-d]pyrimidine and their derivatives were synthesized by using 4-(4chlorophenyl)-3-methyl-1-phenyl-4,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-amine as a starting material. Twenty new heterocyclic containing a pyrazolo[3,4-d]pyrimidine ring were thus prepared in PEG-400 as a green reaction medium. The biological screening(More)
Synthesis of metal nanoparticles for improving therapeutic index and drug delivery is coming up as an attractive strategy in the mainstream of cancer therapeutic research. In the present study, curcumin-capped copper nanoparticles (CU-NPs) were evaluated as possible inhibitors of in vivo angiogenesis, pro-angiogenic cytokines involved in promoting tumor(More)
Shigella species were discovered over 100 years ago by a Japanese microbiologist named Shiga, for whom the genus is named. Shigella organisms are a group of gram-negative, facultative intracellular pathogens. They were recognized as the etiologic agents of bacillary dysentery or shigellosis in the 1890s. These organisms are members of the family(More)
OBJECTIVE The present study was designed to elucidate the impact of oral administration of aluminium chloride for 28 days with respect to oxidative stress in the cerebral cortex of female rats. Further, to investigate the potentials of Coenzyme (Co) Q10 (4, 8, and 12 mg/kg, i.p.) in mitigating the detrimental changes. MATERIALS AND METHODS Biochemical(More)