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Lipocalin (LCN) 2 Mediates Pro-Atherosclerotic Processes and Is Elevated in Patients with Coronary Artery Disease
Background Lipocalin (LCN) 2 is associated with multiple acute and chronic inflammatory diseases but the underlying molecular and cellular mechanisms remain unclear. Here, we investigated whetherExpand
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NADPH oxidase NOX2 mediates TLR2/ 6‐dependent release of GM‐CSF from endothelial cells
NADPH oxidase–generated reactive oxygen species (ROS) from immune cells are well known to be important for pathogen killing in response to TLR ligands. Here, we investigated a new aspect of NADPHExpand
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Targeting Tumor Necrosis Factor-α with Adalimumab: Effects on Endothelial Activation and Monocyte Adhesion
Objective It is well known that atherosclerotic inflammatory vascular disease is critically driven by oxidized lipids and cytokines. In this regard, tumor necrosis factor (TNF)-α is known as aExpand
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  • Open Access
Anti-tumor necrosis factor-α therapy increases plaque burden in a mouse model of experimental atherosclerosis.
BACKGROUND AND AIMS Atherosclerosis is critically fueled by vascular inflammation through oxidized lipids and inflammatory cytokines such as tumor necrosis factor (TNF)-α. Genetic disruption of Tnf-αExpand
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The Lipopeptide MALP-2 Promotes Collateral Growth
Beyond their role in pathogen recognition and the initiation of immune defense, Toll-like receptors (TLRs) are known to be involved in various vascular processes in health and disease. WeExpand
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  • Open Access
Abstract 3229: Energy restriction caused by the glycolytic inhibitor, 2-Deoxy-D-Glucose inhibits chemical induced carcinogenesis in mice
Enhanced glucose metabolism is a fundamental metabolic change in most of the tumors which drives the process of tumorigenesis. Dietary Energy Restriction (DER) is a promising approach to target thisExpand
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Suppressor of Cytokine Signaling 1 is Involved in Gene Regulation Which Controls the Survival of Ly6Clow Monocytes in Mice.
BACKGROUND/AIMS Inflammatory processes are controlled by the fine-tuned balance of monocyte subsets. In mice, different subsets of monocytes can be distinguished by the expression of Ly6C that isExpand
Identification of microRNAs involved in NOD-dependent induction of pro-inflammatory genes in pulmonary endothelial cells
The nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 are mammalian cytosolic pattern recognition receptors sensing bacterial peptidoglycan fragments in order to initiateExpand