Raffaele Bianco

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In this paper we discuss the limitations of current evolutionary robotics models and we propose a new framework that might solve some of these problems and lead to an open-ended evolutionary process in hardware. More specifically, the paper describes a novel approach, where the usual concepts of population, generations and fitness are made implicit in the(More)
We describe the results of a set of evolutionary experiments in which a simulated robotic arm provided with a two-fingered hand has to reach and grasp objects with different shapes and orientations on the basis of simple tactile information. Obtained results are rather encouraging and demonstrate that the problem of grasping objects with characteristics(More)
Although cytotoxic chemotherapy for human cancer has been reported to induce alterations in intestinal permeability, its effects on the absorp tive process are still controversial. We have studied mediated and nonmediated absorption in 10 patients with metastatic breast cancer before and after treatment with Adriamycin by the use of specific test sugars(More)
PURPOSE The epidermal growth factor receptor (EGFR) autocrine pathway plays an important role in cancer cell growth. Vascular endothelial growth factor (VEGF) is a key regulator of tumor-induced endothelial cell proliferation and vascular permeability. Enhanced cyclooxygenase-2 (COX-2) expression has been linked to cancer cell proliferation, EGFR(More)
Topoisomerase II (Topo II) is an essential enzyme that catalyzes the breakage of double-strand DNA and is the target of several effective anticancer drugs, including the epipodophyllotoxins. The regulatory subunits of the cyclic AMP-dependent protein kinase are differentially expressed in normal and cancer cells. The RIa subunit is overexpressed in cells(More)
cAMP and PKA stimulate or inhibit cell proliferation, depending on the cell type. For example, cAMP rise induces G1 arrest in NIH 3T3 fibroblast, but it is an essential mitogenic signal in TSH-dependent cells. In both cell types, cAMP stimulates survival (Affaitati et al., 2003). PI3K has been found essential for cAMP induced cell growth and survival in(More)
A new method specific for the determination and unambiguous confirmation of the antibiotic valnemulin in feed for all animal species is described. Simple clean-up based on solvent extraction and liquid partition is carried out prior to determination by liquid chromatography coupled to electrospray tandem mass spectrometry on a hybrid QTRAP 4000 system, in(More)
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