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OBJECTIVE Obesity is associated with a state of chronic low-grade inflammation. Myeloperoxidase (MPO) plays an important role in the initiation and progression of acute and chronic inflammatory diseases, such as cardiovascular disease (CVD). The objectives of the current study were to evaluate plasma MPO levels in prepubertal obese children and to determine(More)
Variants in the neuropeptide Y (NPY) gene have been associated with obesity and its traits. The objective of the present study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the NPY gene with obesity, metabolic syndrome features, and inflammatory and cardiovascular disease (CVD) risk biomarkers in Spanish children. We recruited(More)
OBJECTIVE To describe vitamin intakes in Spanish food patterns, identify groups at risk for inadequacy and determine conditioning factors that may influence this situation. DESIGN Pooled-analysis of eight cross-sectional regional nutrition surveys. SUBJECTS Ten thousand two hundred and eight free-living subjects (4728 men, 5480 women) aged 25-60 years.(More)
OBJECTIVE To evaluate the association between waist-to-height ratio (WHtR) and specific biomarkers of inflammation, CVD risk and endothelial dysfunction in prepubertal obese children. DESIGN Prospective, multicentre case-control study matched by age and sex. SETTING Children were recruited between May 2007 and May 2010 from primary-care centres and(More)
Variants in the FTO gene have been associated with obesity in children, but this association has not been shown with other biomarkers. We assessed the association of 52 FTO polymorphisms, spanning the whole gene, with obesity and estimated the influence of these polymorphisms on anthropometric, clinical and metabolic parameters as well as inflammation and(More)
BACKGROUND. Agenesis of the corpus callosum is generally associated with other developmental defects of the cerebrum. Some familial cases have been reported. CASES REPORTS Case n. 1. A 6 year-old girl was examined because of developmental retardation, first noted at the age of 3 months. There was no consanguinity but 2 girls, cousins of the father, died at(More)
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