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PURPOSE Sorafenib is a small molecule inhibitor of multiple signaling kinases thought to contribute to the pathogenesis of many tumors including brain tumors. Clinical trials with sorafenib in primary and metastatic brain tumors are ongoing. We evaluated the plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of sorafenib after an intravenous (IV)… (More)
Dedicated to Mark Strutt (1957-2007), who worked tirelessly for a more sustainable world and who inspired and initiated the writing of this paper. One sentence definition 2 A. The benefits of ecological farming 2 B. The current model of destructive, polluting agriculture 2 C. Facts and figures (backed by recent scientific studies) 3 The problem 3 The… (More)
The aim of the study is to compare distinct morphological characters of Metrodorea (Rutaceae) with those of related genera, under a phylogenetic approach. Morphoanatomy of leaves was analyzed, and data concerning reproductive structures were compiled from the literature. We used available molecular sequences to recover a maximum likelihood tree, and we… (More)
This paper presents an application of the active disturbance rejection control approach for humanoid robot stable walking, which is a control strategy based on the extended state observer and cascade integrator canonical form features from modern control theory to deal with disturbances, nonlinearities and unmodeled dynamics. The proposed controller is… (More)
Universidade Federal do Rio de Janeiro, como parte dos requisitos necessáriosà obtenção do título de Mestre em Engenharia de Sistemas e Computação.