Rafael Siva Prudêncio

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The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of epiisopiloturine (1), an imidazole alkaloid found in the leaves of Pilocarpus microphyllus. The anti-inflammatory activity of 1 was evaluated using several agents that induce paw edema and peritonitis in Swiss mice. Paw tissue and peritoneal fluid samples were(More)
OBJECTIVES The aim of this study was to evaluate the protective effect of the sulfated-polysaccharide (PLS) fraction extracted from the seaweed Gracilaria birdiae in rats with trinitrobenzenesulfonic acid (TNBS)-induced colitis. METHODS In the experiments involving TNBS-induced colitis, rats were pretreated with polysaccharide extracted from G. birdiae(More)
The sulfated polysaccharide (PLS) fraction of Agardhiella ramosissima was characterized by microanalysis, infrared spectroscopy, NMR and gas-liquid-chromatography-mass-spectrometry. The main constituent of PLS was the ι carrageenan. The monosaccharide composition of the PLS showed galactose, 3,6-anhydrogalactose and 6-O-methylgalactose. The PLS (30 mg(More)
In the present study, the brown seaweed Spatoglossum schroederi was submitted to extraction procedures in order to obtain methanol (MET) extract and its hexane (HEX) and chloroform (CLR) fractions. All samples were evaluated for total phenolic and flavonoid contents as well as antioxidant and anti-inflammatory properties. The HEX fraction was the richest in(More)
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