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Cks is an evolutionarily conserved protein that regulates cyclin-dependent kinase (CDK) activity. Clarifying the underlying mechanisms and cellular contexts of Cks function is critical because Cks is essential for proper cell growth, and its overexpression has been linked to cancer. We observe that budding-yeast Cks associates with select phosphorylated(More)
In this article, the combination of commercial polymeric microparticles (OASIS MCX) and cobalt ferrite nanoparticles is evaluated in dispersive micro-solid phase extraction (D-μSPE) for the determination of six nitroaromatic hydrocarbons in water. The high affinity of the polymeric material toward the target analytes as well as the magnetic behavior of(More)
A simple, rapid, solventless method for the determination of trihalomethanes (THMs) (chloroform, bromodichloromethane, dibromochloromethane and bromoform) in water samples is presented. The analytes are extracted from the headspace of the aqueous matrix into a 2 microL drop of the ionic liquid 1-octyl-3-methyl-imidazolium hexafluorophosphate working at 30(More)
The paper presents a general overview of the use of nanoparticles to perform sample preparation. In this way the main uses of nanoparticles to carry out solid phase extraction, solid phase microextraction, liquid-liquid extraction and filtration techniques are described for a wide range of nanoparticles including carbon nanoparticles, metallic, silica and(More)
In this paper, ionic liquid coated magnetic nanoparticles (IL-MNPs) have been prepared by covalent immobilization. The as-synthesized MNPs have been successfully used as sorbent for the extraction of polycyclic aromatic hydrocarbons (PAHs) from water samples, the analytes being finally determined by gas chromatography/mass spectrometry. The influence of(More)
Antidepressants are widely used for the treatment of psychiatric disorders and therefore their monitoring in biological fluids is quite important taking into account that they can produce dangerous biochemical imbalances in toxic doses. A method for the determination of antidepressants in urine samples is presented using solid-phase extraction (SPE) and(More)
A simple and rapid method for the determination of seven phenothiazines derivatives (chlorpromazine, promethazine, levomepromazine, prochlorperazine, trifluoperazine, fluphenazine and thioridazine) in human urine samples is presented. The analytes are extracted from the sample in 50 microL of the ionic liquid 1-butyl-3-methyl-imidazolium hexafluorophosphate(More)
The advantages of surfactant-coated carbon nanotubes (CNTs) as coadjutants in liquid-liquid extraction are systematically considered. The effect of the CNT state (dispersed or suspended in an aqueous medium) is characterized by the single-component solid-liquid isotherms exemplified for benzene. Adsorption isotherms are obtained by means of a(More)
In this article, a solid-phase extraction approach, which takes advantage of the good extraction capabilities of hydrophobic magnetic nanoparticles (MNPs), is presented. The new approach involves the deposition of a thin layer of MNPs in a dedicated stirring unit based on the dual function of a mini-magnet. The system allows the extraction of the analytes(More)
In this article, effervescence assisted dispersive liquid-liquid microextraction with extractant removal by magnetic nanoparticles is presented for the first time. The extraction technique makes use of a mixture of 1-octanol and bare Fe3O4 magnetic nanoparticles (MNPs) in acetic acid. This mixture is injected into the sample, which is previously fortified(More)