Rafael Gafoor

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BACKGROUND While recent research points to the potential benefits of clinical intervention before the first episode of psychosis, the logistical feasibility of this is unclear. AIMS To assess the feasibility of providing a clinical service for people with prodromal symptoms in an inner city area where engagement with mental health services is generally(More)
BACKGROUND Early specialised care may improve short-term outcome in first-episode non-affective psychosis, but it is unclear if these benefits endure. AIMS To assess the long-term effect of early intervention in psychosis. METHOD Individuals with first-episode psychosis were randomised to specialised care or care as usual (trial number: ISRCTN73679874).(More)
OBJECTIVE To compare the efficacy and adverse effect profiles of 2 widely used atypical antipsychotics in the short-term phase of first-episode schizophrenia in patients who were treatment-naive. A secondary objective was to establish the effective dose of these drugs in this context. METHODS A total of 72 patients with a first episode of schizophreniform(More)
Abdominal aortic aneurysm (AAA) is a relatively common disease of the elderly presenting as progressive dilatation of the abdominal aorta. The condition shows a pronounced tendency to cluster in families, indicating a genetic component in the disease aetiology. We have screened the cholesteryl ester transfer protein (CETP) gene, which has been proposed as a(More)
Clozapine is indicated for the treatment of patients intolerant of conventional antipsychotic agents. It is often used to treat those patients who have developed movement disorders while on conventional antipsychotics. We report three cases of dyskinesia associated with clozapine induction. We suggest a mechanism that might explain an underlying(More)
any patient having periods of discontinuation), although 5 cases occurred within 4 months of initiating treatment. No one was on high-dose clozapine (9600 mg/d), but concurrent medications were frequently present and 1 patient was receiving electroconvulsive therapy. Several types of colitis were reported, including 2 cases each of necrotizing and(More)
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