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— Many disorders that affect the brain can cause shape changes in subcortical structures, and these may provide biomarkers for disease detection and progression. Automatic tools are needed to accurately identify and characterize these alterations. In recent work, we developed a surface multivariate tensor-based morphometry analysis (mTBM) to detect(More)
Many children born preterm exhibit frontal executive dysfunction, behavioral problems including attentional deficit/hyperactivity disorder and attention related learning disabilities. Anomalies in regional specificity of cortico-striato-thalamo-cortical circuits may underlie deficits in these disorders. Nonspecific volumetric deficits of striatal structures(More)
Regional morphometic analyses of the corpus callosum (CC) are typically done using the 2D medial section of the structure, but the shape information is lost through this method. Here we perform 3D regional group comparisons of the surface anatomy of the CC between 12 preterm and 11 term-born neonates. We reconstruct CC surfaces from manually segmented brain(More)
Neurocognitive and neurosensory deficits in preterm neonates are likely related to abnormal development and injury of subcortical structures including the corpus callosum, thalamus, basal ganglia and hippocampus. Most surface morphometric work in neonates has been dedicated to studying the cerebral cortex. However, changes in surface morphometry of the(More)
Prematurity is one of the leading causes of mental retardation in the United States. Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and in designing treatments. Using brain structural MRI, we perform regional group comparisons of the surface anatomy of subcortical structures between healthy(More)
Thalamic structural co-variation with cortical regions has been demonstrated in preterm infants, but its relationship to cortical function and severity of non-cystic white matter injury (non-cystic WMI) is unclear. The relationship between thalamic morphology and both cortical network synchronization and cortical structural connectivity has not been(More)
The posteromedial cortex (PMC) including the posterior cingulate, retrosplenial cortex, and medial parietal cortex/precuneus is an epicenter of cortical interactions in a wide spectrum of neural activity. Anatomic connections between PMC and thalamic components have been established in animal studies, but similar studies do not exist for the fetal and(More)
Preterm neonates are at higher risk of neurocognitive and neurosensory abnormalities. While numerous studies have looked at the effect of prematurity on brain anatomy, none to date have attempted to understand the relative pose of subcortical structures and to assess its potential as a biomarker of abnormal growth. Here, we perform the first relative pose(More)
Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization of the abnormalities within the subnuclei(More)
A major challenge in the diagnosis and treatment of brain tumors is tissue heterogeneity leading to mixed treatment response. Additionally, they are often difficult or at very high risk for biopsy, further hindering the clinical management process. To overcome this, novel advanced imaging methods are increasingly being adapted clinically to identify useful(More)