Rafael Ceschin

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The use of the adaptive statistical iterative reconstruction (ASIR) algorithm has been shown to reduce radiation doses in adults undergoing abdominal CT studies while preserving image quality. To our knowledge, no studies have been done to validate the use of ASIR in children. To retrospectively evaluate differences in radiation dose and image quality in(More)
BACKGROUND AND PURPOSE Abnormal cerebral microstructure has been documented in term neonates with congenital heart disease, portending risk for injury and poor neurodevelopmental outcome. Our hypothesis was that preterm neonates with congenital heart disease would demonstrate diffuse cerebral microstructural abnormalities when compared with critically ill(More)
BACKGROUND AND PURPOSE Iterative reconstruction techniques facilitate CT dose reduction; though to our knowledge, no group has explored using iterative reconstruction with pediatric head CT. Our purpose was to perform a feasibility study to assess the use of ASIR in a small group of pediatric patients undergoing head CT. MATERIALS AND METHODS An(More)
Many disorders that affect the brain can cause shape changes in subcortical structures, and these may provide biomarkers for disease detection and progression. Automatic tools are needed to accurately identify and characterize these alterations. In recent work, we developed a surface multivariate tensor-based morphometry analysis (mTBM) to detect(More)
The posteromedial cortex (PMC) including the posterior cingulate, retrosplenial cortex, and medial parietal cortex/precuneus is an epicenter of cortical interactions in a wide spectrum of neural activity. Anatomic connections between PMC and thalamic components have been established in animal studies, but similar studies do not exist for the fetal and(More)
Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization of the abnormalities within the subnuclei(More)
BACKGROUND AND PURPOSE Immune response to cancer therapy may result in pseudoprogression, which can only be identified retrospectively and may disrupt an effective therapy. This study assesses whether serial parametric response mapping (a voxel-by-voxel method of image analysis also known as functional diffusion mapping) analysis of ADC measurements(More)
OBJECTIVE Late preterm birth confers increased risk of developmental delay, academic difficulties and social deficits. The late third trimester may represent a critical period of development of neural networks including the default mode network (DMN), which is essential to normal cognition. Our objective is to identify functional and structural connectivity(More)
BACKGROUND The purpose of this study was to assess the effects of dental flossing on the microbial composition of interproximal plaque samples in matched twins. METHODS The study was a two-treatment, examiner-masked, randomized, parallel-group, controlled study. Fifty-one twin pairs between 12 and 21 years of age were randomized to a 2-week supervised and(More)
Many children born preterm exhibit frontal executive dysfunction, behavioral problems including attentional deficit/hyperactivity disorder and attention related learning disabilities. Anomalies in regional specificity of cortico-striato-thalamo-cortical circuits may underlie deficits in these disorders. Nonspecific volumetric deficits of striatal structures(More)