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  • Benjamin M. Bolstad, Rafael A. Irizarry, Magnus Åstrand, Terence P. Speed
  • Computer Science, Medicine
  • Bioinform.
  • 2003 (First Publication: 22 January 2003)
  • MOTIVATION When running experiments that involve multiple high density oligonucleotide arrays, it is important to remove sources of variation between arrays of non-biological origin. Normalization isContinue Reading
  • Rafael A. Irizarry, Christine Ladd-Acosta, +11 authors Andrew P. Feinberg
  • Medicine, Biology
  • Nature Genetics
  • 2009 (First Publication: 1 February 2009)
  • For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of oncogenes and hypermethylation of tumor suppressor genes. However,Continue Reading