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OBJECTIVE To compare the incidence rates for AD among elderly African-American, Caribbean Hispanic, and white individuals and to determine whether coincident cerebrovascular disease contributes to the inconsistency in reported differences among ethnic groups. METHODS This was a population-based, longitudinal study over a 7-year period in the Washington(More)
OBJECTIVES To identify novel loci for late-onset Alzheimer disease (LOAD) in Caribbean Hispanic individuals and to replicate the findings in a publicly available data set from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study. DESIGN Nested case-control genome-wide association study. SETTING The Washington Heights-Inwood(More)
BACKGROUND Rates of dementia may vary among ethnoracial groups. Any real and substantial such difference would merit serious attention by health planners, clinicians and those seeking to advance our understanding of the etiology of this group of disorders. METHODS Randomly selected elderly persons from each of three ethnoracial groups (Latinos,(More)
A brief diagnostic battery of neuropsychological tests was developed for a large-scale epidemiological study of dementia. We operationally defined dementia as defective memory and defective performance in at least two other areas, including orientation, abstract reasoning, construction, and language. Criterion scores for defining defective performance on(More)
CONTEXT Although the association between Alzheimer disease (AD) and the apolipoprotein E epsilon4 (APOE-epsilon4) allele has been confirmed worldwide, it appears to be inconsistent among African Americans, Hispanics, and Nigerians. OBJECTIVE To investigate the association between the APOE-epsilon4 allele and AD in elderly African Americans, Hispanics, and(More)
OBJECTIVE To investigate the association between Alzheimer disease (AD) and variant alleles in SORL1 using a series of single nucleotide polymorphisms (SNPs) in an urban, multiethnic, community-based population. DESIGN We used a nested case-control analysis in a population-based, prospective study of aging and dementia in Medicare recipients, 65 years and(More)
BACKGROUND Until now there has been only one community-based study to examine interethnic differences in the prevalence of essential tremor (ET). The study suggested a higher prevalence among whites than African Americans. The present study is the first to examine differences in the prevalence of ET among Hispanics, African Americans, and whites. (More)
A b s t r a c t Background: Telemedicine is a promising but largely unproven technology for providing case management services to patients with chronic conditions who experience barriers to access to care or a high burden of illness. Methods: The authors conducted a randomized, controlled trial comparing telemedicine case management to usual care, with(More)
OBJECTIVE To screen for posttraumatic stress disorder (PTSD) in primary care patients 7-16 months after 9/11 attacks and to examine its comorbidity, clinical presentation and relationships with mental health treatment and service utilization. METHOD A systematic sample (n=930) of adult primary care patients who were seeking primary care at an urban(More)
CONTEXT Genetic determinants of Alzheimer disease (AD) have not been comprehensively examined in Caribbean Hispanics, a population in the United States in whom the frequency of AD is higher compared with non-Hispanic whites. OBJECTIVE To identify variant alleles in genes related to familial early-onset AD among Caribbean Hispanics. DESIGN AND SETTING(More)