Rae McLellan

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The present study investigated the effects of the cannabinoid receptor agonist CP 55,940 (1-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol) and the cannabinoid receptor antagonist SR 141716A (N-(piperidin-l-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me thyl-1 H-pyrazole-3-carboxamide hydrochloride) on ultrasonic(More)
The fluoroquinolone antibacterial agents have gained widespread use in the treatment of a broad range of bacterial infections. We recently described a possible interaction concerning the concomitant use of cyclosporine A and norfloxacin in pediatric renal transplant patients. We examined the effect of two common fluoroquinolone antibiotics on cytochrome(More)
Reducing the supply voltage to reduce dynamic power consumption in CMOS devices, inadvertently will lead to an exponential increase in leakage power dissipation. In this work we explore an architectural idea to reduce leakage power in data caches. Previous work has shown that cache frames are “dead” for a significant fraction of time [14]. We are exploiting(More)
It is now established that inflammatory stimuli such as lipopolysaccharides (LPS) and polyinosinic acid:polycytidylic (polyIC) suppress hepatic expression of cytochrome P450 (P450) genes in rat liver. Previous studies have suggested that LPS- or polyIC-induced downregulation of P450 was due to endogenously released inflammatory cytokines such as tumor(More)
Prophylactic treatment with norfloxacin was initiated in a group of pediatric patients undergoing renal transplantation who were receiving cyclosporine and were susceptible to recurrent urinary tract infections. At discharge from the hospital, the mean daily dose of cyclosporine needed to maintain trough cyclosporine blood levels of 150 to 400 ng/ml was 4.5(More)
Maternal varicella infections during pregnancy can be either benign or disastrous for the infant according to the timing of infection during gestation. We report a case of varicella occurring at term that was managed successfully. Appropriate management includes tocolysis, unless contraindicated, and varicella-zoster immune globulin (VZIG) administered to(More)
We present Shallow MAC (ShMAC), a fixed-input-length message authentication code that performs most of the computation <i>prior</i> to the availability of the message. Specifically, ShMAC&#8217;s message-dependent computation is much faster and smaller in hardware than the evaluation of a pseudorandom permutation (PRP) and can be implemented by a small(More)
Numerous solutions have been proposed in the literature to eliminate reordering in load-balanced switch fabrics. A common approach involves uniform frames, in which every cell of a frame has the same destination. This can achieve 100% throughput with relatively small average traffic delay; however, the worst-case delay may be unbounded. We show that with a(More)
INTRODUCTION Bladder cancer is the most common malignant tumor of the urinary system. Tobacco smoking has been implicated as a major risk factor for the development of bladder cancer and Nova Scotia has some of the highest smoking rates in Canada. We examined trends in the incidence of bladder cancer in Nova Scotia between 1980 and 1999. MATERIALS AND(More)