Radu Cristian Ionescu

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UNLABELLED We report on a new concept for profiling genetic mutations of (lung) cancer cells, based on the detection of patterns of volatile organic compounds (VOCs) emitted from cell membranes, using an array of nanomaterial-based sensors. In this in-vitro pilot study we have derived a volatile fingerprint assay for representative genetic mutations in(More)
AIM To study the feasibility of a novel method in nanomedicine that is based on breath testing for identifying Alzheimer's disease (AD) and Parkinson's disease (PD), as representative examples of neurodegenerative conditions. PATIENTS & METHODS Alveolar breath was collected from 57 volunteers (AD patients, PD patients and healthy controls) and analyzed(More)
The ante-mortem diagnosis of Parkinson's disease (PD) still relies on clinical symptoms. Biomarkers could in principle be used for the early detection of PD-related neuronal damage, but no validated, inexpensive, and simple biomarkers are available yet. Here we report on the breath-print of presymptomatic PD in rats, using a model with 50% lesion of(More)
A cross-reactive array of polycyclic aromatic hydrocarbons and single wall carbon nanotube bilayers was designed for the detection of volatile organic compounds (tentatively, hexanal and 5-methyl-undecane) that identify the presence of disease in the exhaled breath of patients with multiple sclerosis. The sensors showed excellent discrimination between(More)
In the present work, we introduce a cross-reactive array of synthetically designed polycyclic aromatic hydrocarbons (PAH) and single-walled carbon nanotube (SWCNT) bilayers and demonstrate the huge potential of the array in discriminating between polar and nonpolar volatile organic compounds (VOCs), as well as between the different VOCs from each subgroup.(More)
AIM The aim of the study was to report the efficacy and tolerability of infliximab therapy in the first 24 patients with refractory and fistulizing Crohn's disease (CD) treated at our center between August 2000-May 2002. PATIENTS AND METHODS The medical records of 24 patients (13 males, 11 females) treated with infliximab for refractory or fistulizing CD(More)
Real-world samples contain reducing and oxidizing chemical agents as well as large and small (bio)molecules, which are polar or nonpolar in nature. Sensing nonpolar analytes, which is of paramount importance for a wide variety of applications, is generally more difficult to achieve than sensing polar analytes. Here, we report on empirical observations of a(More)
AIM To demonstrate the feasibility of nanomaterial-based sensors for identifying patterns of exhaled volatile organic compound of end-stage renal disease (ESRD) and study the impact of hemodialysis (HD) on these patterns. PATIENTS & METHODS Exhaled breath samples were collected from a group of 37 volunteers (26 ESRD HD patients; 11 healthy controls); a(More)
We present a pilot study that aims to examine the possibility to easily and noninvasively detect and discriminate females with ovarian cancer (OC) from females that have no tumor(s) and from females that have benign genital tract neoplasia, using exhaled breath samples. The study is based on clinical samples and data from 182 females, as follows: 48 females(More)
We present the case of a 72-year-old man with atrial fibrillation who developed an embolic occlusion of the superior mesenteric artery. He was successfully treated with local fibrinolysis using streptokinase associated with angioplasty. Such local treatments without the need of surgery are very rarely reported in the literature because of the great(More)