Radhika Dhamija

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Chromosomal abnormalities involving deletions and duplications are known to cause severe developmental disorders, including mental retardation, dysmorphism, and seizures, in children. As the technique of array-based comparative genomic hybridization is being applied more frequently in the diagnostic evaluation of children with developmental disorders, novel(More)
Autoimmunity targeting voltage-gated potassium channel complexes have not been systematically documented in children. Identified in the Neuroimmunology Laboratory records of Mayo Clinic were 12 seropositive children, 7 among 252 Mayo Clinic pediatric patients tested on a service basis for serologic evidence of neurologic autoimmunity (June 2008-April 2010),(More)
BACKGROUND & AIMS Autoimmune gastrointestinal dysmotility is a limited autoimmune dysautonomia occurring idiopathically or in the context of an anatomically remote neoplasm, previously documented or unsuspected. Here we report 24 Mayo Clinic patients in whom the profile of serum autoantibodies aided this diagnosis. METHODS All patients were ascertained(More)
Next generation sequencing panels have revolutionized the diagnostic approach to patients with epilepsy. There are several commercial epilepsy panels available. We assessed the list of genes tested and consent forms for epilepsy panels available at seven laboratories. The panels varied in the number of genes included (70–465 genes). In some panels, genes(More)
About one third of patients with epilepsy are pharmacoresistent. For a subgroup of this population, the ketogenic diet can be highly efficacious and should be considered early. This review discusses the different types of ketogenic diet, proposed mechanism of actions and its evidence for use in children and adults with both generalized and focal epilepsies(More)
PURPOSE To evaluate long-term seizure outcome in children with epilepsy and a focal or hemispheric neuroimaging abnormality. METHODS All children (<18 years and residing in Olmsted County, Minnesota) with new-onset epilepsy diagnosed between 1980 and 2004 and a single focal lesion on neuroimaging were identified by review of the Rochester Epidemiologic(More)
Velocardiofacial syndrome, also known as DiGeorge syndrome, is a multisystem genetic disorder caused by microdeletion of 3.0 megabases (Mb) of DNA on the long arm of chromosome 22. Recently, 22q11.2 deletion syndrome (22q11.2DS) has been recognized as a potential risk factor for the development of Parkinson’s disease (PD). We report on a patient with(More)
A ripiprazole is a relatively new atypical antipsychotic drug used to treat aggression, bipolar disorder, conduct and mood disorder, and Tourette’s syndrome in children and schizophreniarelated mood disturbances in adults. It is believed to have fewer side effects such as weight gain, pancreatitis, and hyperglycemia (1,2). We report a 12-year-old boy who(More)
Moxifloxacin is a newer-generation synthetic fluoroquinolone that is used for treatment of acute bacterial sinusitis, acute exacerbation of chronic bronchitis, community acquired pneumonia, intra-abdominal infections and skin/skin structure infections. We describe a case of fatal hepatotoxicity caused by Moxifloxacin in a 72-year-old man. He presented with(More)