Radhakrishna Bettadapura

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We review tools for structure identification and model-based refinement from three-dimensional electron microscopy implemented in our in-house software package, VOLROVER 2.0. For viral density maps with icosahedral symmetry, we segment the capsid, polymeric, and monomeric subunits using techniques based on automatic symmetry detection and multidomain fast(More)
Whereas traditional finite element methods use meshes to define domain geometry, weighted extended B-spline finite element methods rely on a weight function. A weight function is a smooth, strictly positive function which vanishes at the domain boundary at an appropriate rate. We describe a method for generating weight functions for a general class of(More)
There continue to be increasing occurrences of both atomistic structure models in the PDB (possibly reconstructed from X-ray diffraction or NMR data), and 3D reconstructed cryo-electron microscopy (3D EM) maps (albeit at coarser resolution) of the same or homologous molecule or molecular assembly, deposited in the EMDB. To obtain the best possible(More)
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