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BNL is responsible for the design and construction of the US Spallation Neutron Source (SNS) accumulator ring. Titanium Nitride (TiN) coating on the stainless steel vacuum chamber of the SNS accumulator ring is needed to reduce the secondary electron yield (SEY) and the undesirable resonant multiplication of electrons. The total SEY of TiN coated stainless(More)
The application of molecular biological tools to the study of cancer has significantly advanced the field of human cancer research. Such study has demonstrated the involvement of two classes of highly conserved cellular genes in the malignant transformation process: oncogenes and tumor suppressor genes. Despite these advances in the molecular biology of(More)
Aberrant expression of TGF-alpha is associated with human malignant oral epithelium. Experiments were initiated to determine the cellular sources of transforming growth factor-alpha (TGF-alpha) in human oral cancer. Ten freshly resected human oral cancers and four specimens of normal human oral epithelium were studied by in situ hybridization and(More)
Alteration in epidermal growth factor receptor (EGFR) expression is frequently associated with malignant transformation of epithelial tissues, including oral mucosa. This study examines the mutations in the coding region of the human EGFR gene in normal and malignant human oral keratinocytes. To examine the intragenic mutations in the human EGFR gene, a(More)
DNA hybridization arrays permit global gene expression profiling to be done in a single experiment. The evolution and challenges of DNA hybridization arrays are reflected in the variety of experimental platforms, probe composition, hybridization/signal detection methods, and bioinformatic interpretation. In tumor biology, DNA hybridization arrays are being(More)
Acanthocephalan parasites can manipulate the behavior of their amphipod intermediate hosts in ways that increase the amphipod's risk of being eaten by a predator that serves as the final host for the parasite. Some asocial amphipod species have been shown to increase the likelihood of aggregation in response to chemical cues associated with predators. If(More)
The Spallation Neutron Source (SNS) ring is designed to accumulate, via H – injection, 1.6x10 14 protons per pulse at 60 Hz and 1 GeV energy [1]. At such beam intensity, electron cloud is expected to be one of the intensity-limiting mechanisms that will complicate ring operation. This paper presents the design of the ring vacuum system and the mitigation(More)
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