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Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring

• J Gorlin, Rachel Yamin, +4 authors J. H. Hartwig
• The Journal of cell biology
• 1990

Actin-binding protein (ABP-280, nonmuscle filamin) is a ubiquitous dimeric actin cross-linking phosphoprotein of peripheral cytoplasm, where it promotes orthogonal branching of actin filaments and… (More)

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation.

• Rachel Yamin, E G Malgeri, J. A. H. Sloane, W T McGraw, Cynthia Abraham
• The Journal of biological chemistry
• 1999

We have investigated the functional relationship between metalloendopeptidase EC 3.4.24.15 (MP24.15) and the amyloid precursor protein involved in Alzheimer's disease (AD) and discovered that the… (More)

Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes.

• Maureen Goldring, James R Birkhead, +5 authors Jane F. Apperley
• The Journal of clinical investigation
• 1994

Immortalized human chondrocytes were established by transfection of primary cultures of juvenile costal chondrocytes with vectors encoding simian virus 40 large T antigen and selection in suspension… (More)

MiR-520d-5p directly targets TWIST1 and downregulates the metastamiR miR-10b

• Pinchas Tsukerman, Rachel Yamin, +4 authors Ofer Mandelboim
• Oncotarget
• 2014

MicroRNAs are key players in most biological processes. Some microRNAs are involved in the genesis of tumors and are therefore termed oncomiRs, while others, termed metastamiRs, play a significant… (More)

Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack.

• Chamutal Gur, Yara Ibrahim, +21 authors Ofer Mandelboim
• Immunity
• 2015

Bacteria, such as Fusobacterium nucleatum, are present in the tumor microenvironment. However, the immunological consequences of intra-tumoral bacteria remain unclear. Here, we have shown that… (More)

Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.

• Noa Stanietsky, Tihana Lenac Roviš, +6 authors Ofer Mandelboim
• European journal of immunology
• 2013

The activity of natural killer (NK) cells is controlled by a balance of signals derived from inhibitory and activating receptors. TIGIT is a novel inhibitory receptor, recently shown in humans to… (More)

Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo.

• Carmela R. Abraham, W T McGraw, Franchot Slot, Rachel Yamin
• Annals of the New York Academy of Sciences
• 2000

The neuropathology of Alzheimer's disease (AD) is characterized by extensive deposition of the toxic amyloid beta peptide (A beta) in selected regions of the brain and brain vasculature (Selkoe,… (More)

Cytokine secretion and NK cell activity in human ADAM17 deficiency.

• Pinchas Tsukerman, Eli Michael Eisenstein, +14 authors Ofer Mandelboim
• Oncotarget
• 2015

Genetic deficiencies provide insights into gene function in humans. Here we describe a patient with a very rare genetic deficiency of ADAM17. We show that the patient's PBMCs had impaired cytokine… (More)

Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity

• Yoav Bauman, N. Drayman, +5 authors Ofer Mandelboim
• Oncotarget
• 2016

Polyomaviruses are a diverse family of viruses which are prevalent in the human population. However, the interactions of these viruses with the immune system are not well characterized. We have… (More)

HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.

• Rachel Yamin, Laura S. M. Lecker, +4 authors Ofer Mandelboim
• Cell reports
• 2016

HCMV is a highly sophisticated virus that has developed various mechanisms for immune evasion and viral dissemination throughout the body (partially mediated by neutrophils). NK cells play an… (More)

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