Rachel Y Chong

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The present study was designed to determine whether there are gender differences in hormonal response patterns to HPA axis activation. To this end, two methods of activating the HPA axis were employed: a standardized psychological stress test and a pharmacological challenge. Healthy subjects (mean age 23.4 years, SD 7.0 years) completed a naloxone challenge(More)
A polymorphism in the mu-opioid receptor (MOR) (A118G) has been shown to increase β-endorphin binding affinity, theoretically placing greater inhibitory tone on hypothalamic corticotropin-releasing hormone (CRH) neurons. We hypothesized that the minor allele (G) would predict cortisol responses to both pharmacological (naloxone) and psychological (stress)(More)
GOALS Surgery accounts for one half, and hospitalizations for one third, of overall costs for patients with Crohn's disease (CD). Infliximab induces remission and heals fistulas in CD but is more costly than traditional therapies. Its impact upon resource use in CD is unknown. STUDY The medical records were reviewed for all CD patients managed at our(More)
The present study was designed to determine whether stress hormones and subjective responses to a psychological stressor were different in nonalcoholic offspring from families with a history of alcohol dependence (family history positive, FHP) than in nonalcoholic offspring without a family history of alcohol dependence (family history negative, FHN).(More)
OBJECTIVE Differences in the hypothalamic-pituitary-adrenal (HPA) axis response to stress may confer differences in susceptibility to a variety of diseases. We hypothesized that whites would differ from blacks in HPA axis response to a psychological stressor. DESIGN Healthy subjects aged 18-30 were recruited from Baltimore, Maryland. At initial(More)
BACKGROUND The epidemiology of inflammatory bowel disease (IBD) is poorly characterized in minorities in the U.S. We sought to enumerate the burden of IBD among racial and ethnic groups using national-level data. METHODS Data from the National Health Interview Survey was used to calculate prevalence and incidence of IBD among adults (≥ 18 years) in 1999.(More)
BACKGROUND Cholecystectomy is recommended during hospitalizations for acute biliary pancreatitis (ABP). OBJECTIVE We sought to assess the population-based effectiveness of index cholecystectomy by using nationwide data. DESIGN Retrospective, cohort study. SETTING All acute-care hospitals in Canada from 2007 to 2010. PATIENTS This study involved(More)
OBJECTIVES:Methicillin-resistant Staphylococcus aureus (MRSA) infection has become increasingly prevalent in US hospitals, and the impact of MRSA on hospitalized inflammatory bowel disease (IBD) patients is unknown.METHODS:We used the Nationwide Inpatient Sample to identify admissions for IBD (n=116,842) between 1998 and 2004. We compared prevalence and(More)
BACKGROUND Methotrexate is steroid-sparing in short-term trials for refractory Crohn's disease. This study assesses the impact of dosing and administration on the long-term utility of methotrexate in Crohn's disease. METHODS The efficacy and tolerability of methotrexate were assessed in all refractory Crohn's disease patients treated at the University of(More)
of villous atrophy, present in nearly half of those ultimately diagnosed with celiac sprue, with a specificity of 97%. Mosaic pattern was much less sensitive, yet quite specific. The odds ratios for loss of folds and mosaic pattern were also significantly different from one, with p-values of less than 0.001 and 0.29, respectively. Nodularity and scalloping(More)
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